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01:447:203
Honors Computational Genetics (Honors) (3)
Honors computational genetics is a computer-based laboratory course that introduces students to the use of computers in biological research. This course is for students who are thinking of careers at the intersection of life sciences, statistics, and/or computer science, particularly students who are considering majoring in Genetics. The course fulfills the laboratory requirement for the Genetics major. In the first half of the course, students will receive instruction in introductory computer programming (Python). In the second half of the course, students will practice writing code in Python via in-depth computational projects in genetics and genomics. Each class consists of a mixture of lecture and computer-based demos and/or exercises, as well as time for students to work on assignments. The course provides the introductory skills needed to conduct basic computational research in the life sciences, including many aspects of computer programming and genomic data analysis. Prior experience with computer programming is neither necessary nor is it expected for students who enroll in this course.
This course is for freshman or sophomore Honors students who are thinking of careers at the intersection of life sciences, statistics, and/or computer science, particularly students who are considering majoring in Genetics. The course fulfills the laboratory requirement for the Genetics major.The course fulfills the laboratory
requirement for the Genetics major.
Prerequisites: Students must be in their first or second year at Rutgers in an approved Honors program (e.g., the Honors College or the SAS Honors Program). General Biology I (01:119:115) and be at least co-registered for General Biology II (01:119:116)) or have placed out of these two courses (e.g., through AP credit or approved transfer credit). Credit not given for both 01:447:203 and 01:447:302.
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01:447:216
Analysis of Scientific Literature (Honors) (3)
A
systematic approach to the reading, analyzing, and understanding of primary
literature in genetics; emphasis will be placed on data analysis and
experimental design and demystifying the process of reading a scientific
journal article.
Prerequisites: 01:119:115-116. Highly recommended: 01:694:215. Open only to freshmen and sophomores in the SAS or SEBS Honors Program. By permission only.
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01:447:245
Introduction to Cancer (3)
Introduction to Cancer provides the student with an overview of conventional and state-of-the-art aspects of oncogenesis. Students will become familiar with the process involved in neoplastic transformation to the cancer phenotype through aspects of epidemiology, pathophysiology, virology, in vitro and in vivo cellular transformation and genetics. They will then apply these aspects to the understanding of classic therapeutic modalities and new state-of-the-art rational therapies. This comprehensive course will concentrate on the human disease process by applying clinical aspects of oncogenesis during a series of Grand Rounds discussions that will include recent patient clinical cases and their outcomes.
Prerequisites: 01:119:115-116. Credit not given for both this course and 01:447:495.
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01:447:302
Quantitative Biology and Bioinformatics (3)
Introduction
to the use of computers and computer programming to develop applications for
research in genetics and molecular biology. Application topics will include evolutionary genetics,
association analysis and genetics mapping, and structural biology.
Prerequisites: 01:447:380 or 01:447:384. May be used to fulfill an elective requirement or taken instead of 01:447:315 Introduction to Research in Genetics by students majoring in Genetics. Credit not given for both 01:447:203 and 01:447:302.
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01:447:303
Computational Genetics of Big Data (3)
The
main focus of this course is the application of R programming to the analysis
of genetic data, particularly big data sets with multiple measurements. The
primary data sets considered will contain RNA-seq and/or other expression data
for multiple/all genes in a given set of individuals. This course is for junior
or senior students who are thinking of careers at the intersection of life
sciences, statistics, and/or computer science, particularly students who are
majoring in Genetics. The course
fulfills the laboratory requirement for the Genetics major. Students will learn how to acquire such data,
format it for R, plot the data, and perform statistical analyses. In addition,
students will learn how to simulate data under different hypotheses, and how to
perform power and sample size calculations for different statistical methods
applied to real or simulated data. Each
class consists of a mixture of lecture and computer-based demos and/or
exercises, as well as time for students to work on assignments. Guest
investigators will frequently make short presentations (in person or by skype)
to provide illustrations of how programming and informatics is critical for
their research. The course provides the introductory skills needed to conduct
basic computational research in the life sciences, including many aspects of
computer programming and data analysis.
Prerequisites: 01:447:380 or 01:447:384. May be used to fulfill the lab requirement by students majoring in genetics. May be used to fulfill an elective requirement by students majoring in genetics who have already fulfilled the lab requirement with a separate course.
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01:447:315
Introduction to Research in Genetics (3)
Basic principles and methods of research with microbial model systems
used in the analysis and manipulation of genes, followed by a research
project in molecular genetics.
Prerequisites: 01:119:115,116, and 117; and 01:160:161-162, 171 (or equivalent) or 01:160:163-164, 171. May be used to fulfill the lab requirement by students majoring in genetics. May be used to fulfill an elective requirement by students majoring in genetics who have already fulfilled the lab requirement with a separate course. Credit not given for both this course and 01:694:315. Open only to genetics majors.
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01:447:354
Social, Legal, and Ethical Implications of the New Genetics (3)
Social, legal, and ethical implications of new modern
genetic techniques, for example: genetic screening, stem cells and cloning, forensic genetics, genetic
engineering of plants, animals, and humans, genetic enhancement, gene therapy, and the new eugenics.
Prerequisites: Genetics (01:447:380) or Genetics Analysis (01:447:384).
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01:447:356
Evolutionary Medicine (3)
In
this course, we examine human health from an evolutionary perspective,
exploring the impact that our evolutionary heritage has on modern human
diseases, both chronic and infectious. We will learn how the framework of evolutionary
biology and modern genetic tools can inform our understanding of issues
relevant to clinical and public health. Rather than focus on the immediate
mechanisms underlying disease, we will endeavor to understand the ultimate
factors that influence susceptibility, such as past natural selection. The
course topics are wide-ranging, but particular attention is paid to emerging
infectious diseases, as well as non-communicable diseases that may be
exacerbated by facets of modern lifestyles.
Through lectures, critical analysis of the
primary literature and popular science news, and class discussions, students
will learn how evolutionary principles can be practically applied to medicine.
Key readings each session will focus on genetic techniques for understanding
evolutionary medicine, while additional readings will incorporate perspectives
from diverse fields.
By fully participating in this course, students
will be able to appreciate how modern susceptibility to non-communicable and
infectious diseases has been influenced by past evolutionary processes; critically
evaluate evolutionary hypotheses related to health and medicine, including
those found in popular science articles; and know how genetic techniques are
applied within an evolutionary framework to understand ultimate reasons for
disease.
Prerequisites: (01:447:380 or 384) AND (01:960:401 or 01:960:212).
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01:447:370
Developmental Genetics (3)
How genes influence the developmental processes of an organism. Topics include gene
regulatory networks, signaling pathways, stem cell biology, and the role of
developmental genetics in human disease.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:380
Genetics (4)
Introduction to the mechanisms of heredity and evolution. Mechanisms of
Mendelian inheritance, meiosis, recombination, gene mutation, and
mapping, and an introduction to modern biochemical, molecular, and
population genetics.
Lec. 3 hrs., rec. 1 hr. Prerequisites: 01:119:115-116 and 01:160:161-162 or 01:160:163-164. Credit not given for both this course and 01:447:384-385 or 11:067:328 or 11:776:305.
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01:447:382
Genetics Laboratory (1)
Laboratory
to accompany 01:447:380. Not accepted for elective credit for Genetics majors.
Lab. 3 hrs. Pre- or corequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384)
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01:447:384-385
Genetic Analysis I,II (4,4)
Experimental
methods and concepts in genetics, with emphasis on their application to genetic
research. Part I covers transmission genetics and breeding analyses, basic
molecular genetics, isolation and characterization of mutations, and chromosome
structure and function. Part II covers mathematical genetics, recombinant DNA,
genomics, and special topics relevant to modern genetic research.
Open only to majors in genetics or by permission of instructor. Credit not given for both this course and 01:447:380 or 11:067:328 or 11:776:305. Prerequisites for 01:447:384 are 01:119:115-116 (General Biology I & II) or 01:160:161-162 or 01:160:163-164 (General Chemistry I & II).
Prerequisite for 01:447:385 is 01:447:384.
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01:447:390
General Microbiology (4 includes laboratory)
Microorganisms are an essential component of the human environment and are significant not only for the disease they cause, but also for their ecological, agricultural, pharmaceutical, and industrial benefits. This course will introduce students to the physiology, morphology, pathogenicity, and genetics of groups of microorganisms and their applications. The lab component of the course will introduce microscopy and staining techniques, the growth cycle and generation of a standard curve, physiological characteristics of microorganisms, and bacterial transformation. The course is an introduction to the physiology, morphology, pathogenicity, and genetics of groups of microorganisms. Topics include: History and Overview of Microbiology, Cell Structure and function, Microbial Growth, Nutrition, culture, and metabolism, Virology, Bacterial genetics, Microbial evolution and systematics, Bacteria and Archaea, Nutrient cycles, Genetic Engineering and Biotechnology, Waste treatment, Anaerobic respiration and Nitrogen fixation, Antibiotics and chemotherapeutic agents, Normal Flora, Virulence, Toxins, Epidemiology, and Microbial Diseases.
This is an upper-level course that focuses on the basic principles of microbiology. The course is an introduction to the physiology, morphology, pathogenicity, and genetics of groups of microorganisms. Topics include:
Prerequisites: General Biology 01:119:115-116-117 or 01:119:101-102 and General Chemistry 01:160:161-162-171 (or higher) and Organic Chemistry 01:160:307. Credit not given for both this course and 11:680:390.
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01:447:392
Pathogenic Microbiology (3)
This
course will integrate basic microbiology and infectious diseases. The first
quarter of the course will provide the conceptual basis of microbial
morphology, metabolism and growth, heredity and variation, pathogenicity and
antimicrobial chemotherapy. Then this course will introduce the students to one
real life patient case study each week, moving the course toward an
understanding of specific human diseases (e.g., pharyngitis, meningitis) as
might be expected in a clinical environment. Each case will include a patient
history, differential diagnosis, clinical cues, laboratory data, pathogenesis,
treatment and prevention, additional points and references. The objective is
not to attempt to cover every infectious disease or microorganism, but rather
to use examples that would stress the key principles of microbial pathogenesis,
differential diagnosis and appropriate treatment and prevention. This course is
intended for Life Science majors or those with a strong background in the
Biological Sciences.
Prerequisites: General Biology (01:119:115-117), General Chemistry (01:160:161-162-171), and Organic Chemistry (01:160:305. and 01:160:315. Systems Physiology is recommended.
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01:447:406-407
Research in Genetics (3)
Laboratory
research on original problem under the direction of a professor. Written
thesis, oral presentation, and defense required.
Prerequisites: Permission of department and cumulative grade-point average of 2.8 or better. Open only to students majoring in Genetics.
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01:447:408-409
Honors in Genetics (3-6,3-6)
Laboratory research on original problem under the direction of a
professor. Written thesis, oral presentation, and defense required.
Prerequisites: Open by permission to seniors majoring in genetics who meet the requirements for the departmental honors program. Corequisite: 01:447:414 (fall) and 415 (spring).
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01:447:410
Research in Genetics - Writing Intensive (3)
Research in Genetics- Writing Intensive is intended to provide you with an opportunity to engage in original laboratory research under the direct supervision of a faculty mentor, usually in the faculty member¿s research laboratory. You are expected to carry out your own research project. NOTE: this research requires a heavy commitment of time and effort and can impact your performance in coursework, especially if you have not yet managed the foundational material for the discipline. Fulfills the writing and
communication requirements of the SAS Core Curriculum.
Prerequisites: 01:447:302, 447:315, or permission of department. Registration is by special permission only. Cumulative grade-point average of 2.8 or better. Declared genetics major.
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01:447:414
Thesis Writing and Communication in Genetics (1.5)
Assists students with their honors thesis; emphasis will be
on library/internet research and thesis writing. Students will be expected to
write the introduction, methods, and reference sections of their thesis and
outline the results and discussion.
Corequisites: 01:447:408. For seniors completing departmental honors; by special permission only.
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01:447:415
Thesis Writing and Communication in Genetics (1.5)
Assists students with their honors thesis; emphasis will be on library/internet research and thesis writing. Students will be expected to write the introduction, methods and reference sections of their thesis and outline the results and discussion.
Prerequisite: 01:447:408.
Corequisite: 01:447:409. For seniors completing departmental honors; by special permission only.
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01:447:430
Effective Communication Skills in Genetics (3)
Communication is an essential part of science. Whether it is communicating research findings to other scientists or conveying complex concepts to a lay audience, a scientist must be able to effectively communicate their research to succeed. Communication in science is typically through publications, posters, or oral presentations. The goal of this course is to provide students practice in effectively communicating scientific findings. This includes preparing and revising an introduction for scientific papers, writing a research description for general audience, and preparing and giving presentations (both oral and poster).
Prerequisites: Declared major in Genetics; must have completed one semester of Research in Genetics, Advanced Independent Study, or Genetic Counseling Rotation. By special permission only.
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01:447:451
Genomes (3)
This
course will focus on Genomics, Proteomics and Bioinformatics from a Genetics
perspective. Special attention will be given to the organization and
functioning of the human genome.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:460
Genetics of Compulsive Behavior (3)
Compulsive urge can be channeled toward productive endeavors such as a strong drive to succeed in competitions, schooling, and career. On the other hand, improper handling of compulsive urge may lead to problematic behaviors such as alcoholism, drug use, gambling, and other undesirable behaviors. There are also conditions that are medically defined as disorders, with certain types of compulsive behaviors as part of the diagnostic symptoms, such as OCD and ADD/ADHD. There is evidence that genetics contribute to compulsive behavior in humans, and research in animal models has begun to uncover the molecular factors that underlie the genetic basis of compulsive behavior. Discussion
of primary literature and other scientific publications that deal with the
molecular and genetic basis of compulsive behavior. Emphasis will be placed on the development of skills for
critical thinking and effective writing.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:465
Genetic Approaches and Research Analysis (3)
This class will teach students how to read, interpret and analyze research articles. The class will follow an active learning format, where we will discuss seminal and recent research articles in depth: What was the scientific question or problem? What methods and strategies were used to address it? What were the findings and conclusions? What are the alternative interpretations and methods that could have been applied? What questions are remaining?
This class will expose students to a diverse selection of research literature, involving genetic and molecular analyses in model organisms such as mice, worms, flies and yeast. The class series will begin with a research article presented by the teacher. During the majority of the class series, students will be divided into groups of 4-5. Each group will be assigned one research article and be required to work together to a) interpret, b) analyze and c) present the article in the form of an oral presentation to the class. Students will be graded on their ability to perform each of these tasks and on active participation during presentations by other groups. All groups will also be required to complete and be graded on a written discussion summary assignment at the end of each article discussion. This summary assignment may take many forms, e.g., preparation of a graphical abstract, subway advert, or other creative forms of expression.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:470
Evolutionary Developmental Biology (3)
Evolutionary origins of the vertebrate body plan are major problems in biology. While paleontology and comparative anatomy have revealed the evolutionary trajectories of the organs, recent genetics, genomics and embryology are becoming powerful tools to answer classical questions. The goals of this course are twofold; 1) obtain fundamental knowledge of anatomy, embryology, and the latest genomics and 2) learn how to integrate genetics, genomics and embryology to answer evolutionary questions through active discussion in the classroom. The training to discover and answer scientific questions in animal diversity will be performed at the American Museum of Natural History.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:478,479
Special Topics in Genetics (3,3)
Directed readings and discussion of selected topics of special interest in genetics. Topics will vary according to semester and/or instructor.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:480
Topics in Molecular Genetics (3)
Current research topics in microbial and molecular genetics. Lectures,
discussions, and critical analyses of journal articles.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:484
Behavioral and Neural Genetics (3)
Influence
of genetics on the nervous system and behavior of various organisms. Overview
of field including experimental analysis of behavior, development of the
nervous system, and sensory systems. Emphasis on reading and interpreting
original research.
Prerequisites: Genetics (01:447:380) or Genetic Analysis (01:447:384).
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01:447:488
Genetic Counseling Rotation (3)
The
goal of this course is to provide students with an understanding of the genetic
counseling career. Students will be placed at a local Genetic Counseling clinic
to shadow a genetic counselor for one semester. During the semester, the student
is expected to spend 8-9 hours a week at the rotation plus meet weekly with
course director (attendance is mandatory). Course grade will be based on 1)
Case presentation to Genetic Counseling group 2) ten Genetic Counseling case
summary logs, and 3) evaluation by the clinical supervisor.
Prerequisites: Declared Genetics major, cumulative GPA of 2.8 or greater, and accepted into the undergraduate Genetic Counseling Certificate Program (GCCP).
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01:447:489,490
Advanced Independent Study in Genetics (3,3)
Advanced
independent study in Genetics is an opportunity for students to complete a scholarly
project under the direct supervision of a faculty mentor. Projects are varied;
e.g. library research on a topic of mutual interest to both the student and the
faculty member, computer simulations, informative website design, or
development of teaching materials. This course may not used for laboratory
research.
Prerequisites: 01:447:384 and permission of department. Open only to students majoring in Genetics
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