The Molecules of Life: Biochemistry for Everyone (3)
Introductory biochemistry for nonscience majors, this lecture and discussion-format course presents the biochemistry of human health
through the lens of current topics including metabolism, the microbiome,
genetic engineering, and everyday pharmaceuticals. Through independent learning students will delve into current topics that are of particular interest to them through in-class active learning exercises.
Experiments with Green Fluorescent Protein (3)
An introduction to protein biochemistry and protein purification using green fluorescent protein (GFP) as a teaching tool.
Contemporary Issues in Biochemistry (2)
Topics to be covered
in this course include the role of biochemistry in stem cell research;
genetically modified microorganisms, plants, and animals; drug development; and
disease progression. Students will be introduced to these topics by directed
reading from current literature, interactive lectures, and class
discussion. In addition, some amount of
class time will be devoted to introducing students to laboratory research to
prepare them to be productive participants in the laboratory. Students will be expected to be active
participants in the class discussions, and will also be required to submit
short essays on the selected topics throughout the semester.
Honors Seminar (3)
The topic for each semester addresses current issues
from the perspectives of the humanities, sciences, and social sciences.
Open only to honors students (SEBS Honors Program, SAS Honors Program, and Honors College) or by permission of instructor.
Introductory Biochemistry (3)
The chemistry and metabolism of proteins, carbohydrates, lipids, nucleic acids, and other biologically important compounds.
Prerequisites: 01:160:209 or 307-308 or 315-316.
Introductory Biochemistry Laboratory (1)
Techniques used in research, clinical, and food laboratories, including tests of biological materials, methods of separations, and determinations of enzyme activities.
Lab. 3 hrs. Pre- or corequisite: 11:115:301 or 403.
Ethics in Biochemical Research (3)
Exploration of ethical issues in biochemistry, genetics, and molecular biology
including recombinant DNA technology, genetically modified organisms,
stem cell research, scientific patents, and DNA databases.
Prerequisites: 01:119:115-116,117 (formerly 01:119:101-102).
General Biochemistry (4,3)
A comprehensive survey of the chemistry and metabolism of biological compounds, including proteins, polysaccharides, lipids, and nucleic acids. Enzyme kinetics, bioenergetics, organelles, and cellular organization. Expression and processing of biological information, including DNA replication; transcription into RNA; translation into protein, regulation, and recombinant DNA techniques. A detailed computer laboratory study of structural biology, including protein and nucleic acid three-dimensional structures and the interactions between these and ligands.
Prerequisites: 01:160:307-308 or 315-316 with grades of C or better.
Problem Solving in Biochemistry (2)
Modern instrumentation and analytical techniques used in biochemistry research. Observation of experiments followed by discussion of techniques and problems.
Rec. 1 hr., lab. 1.5 hrs.
Protein and Enzyme Chemistry (3)
Assay and purification of enzymes and other proteins. Chemical modification, site-directed mutagenesis, and enzyme kinetics as tools in understanding structure-function relationships and enzyme mechanisms. Mechanisms of selected enzymes.
Prerequisites: 11:115:403 and 413, or equivalents.
Experimental Biochemistry (3,3)
Isolation, characterization, and quantitative determination of biological compounds. Spectrophotometric and titrimetric analyses; chromatography and gel electrophoresis; high performance liquid chromatography. Isolation and characterization of enzymes, nucleic acids, and lipids. Graphing and statistical treatment using computers.
Lec. 1 hr. (for 413), 55-min. (for 414), lab. 4.5 hrs (for both 413 and 414). Corequisites: 11:115:403,404. Recommended: 01:447:380.
Biochemistry of Cancer (3)
DNA damage/repair mechanisms; oncogenes/tumor suppressor genes; signaling pathways; apoptosis/cell death; the cell cycle; metastasis-cell, cell contact, and protease activation; tumor growth and angiogenesis; genetic events; genetic polymorphisms; chemical carcinogenesis; chemotherapeutic targeting.
Biochemical Mechanisms of Toxicology (3)
General principles and mechanisms of biochemical toxicology, including pharmacokinetics and pharmacodynamics. Examples of metabolism of industrial compounds, organic agrichemicals, and carcinogens.
Prerequisites: 01:119:115-116,117 (formerly 01:119:101-102), 01:160:307-308 or 315-316. Pre- or corequisites: 11:115:403,404 or equivalent. Recommended: 01:146:356 or equivalent.
Fundamentals of Genomics (3)
This course will provide an introduction to genome science
to undergraduate and graduate students with a variety of backgrounds such
as biochemistry, microbiology, animal,
and plant science who are confronted with the growing influence of this field
in their work but may not be knowledgeable in its uses and limitations. The
lectures will provide an overview of genomics technology and provide real-life
examples in the life sciences.
Prerequisite: 01:119:102 or 01:119:116. Formerly 11:216:423.
Homology Modeling of Proteins (3)
Computer construction of models of the three-dimensional structure of proteins, based on known structures of proteins with related sequences. Interpretation and prediction of function based on the modeled structure.
Special Topics in Biochemistry (1)
Self-paced computer tutorials in structural biochemistry; designed to supplement courses in molecular biosciences.
Molecular Toxicology (1.5)
Principles and methodologies of toxicology, at the organismal and molecular levels.
One 80-min. lec. Prerequisites: A course in biochemistry, a course in toxicology, laboratory experience.
Molecular Toxicology Laboratory (3)
Techniques currently applied in public and private toxicology laboratories.
One 80-min. pre-lab., one 3-hr. lab.
Biochemical Separations (3)
Basic theory and practice of separating biological molecules. Chromatography, centrifugation, electrophoresis, ultrafiltration, and general methods of extracting and purifying proteins, nucleic acids, carbohydrates, and other biological molecules.
Prerequisites: 11:115:301 or 403, 11:115:313 or 413.
Advanced Methods for 3-D Structure Determination of Biomolecules (3)
This course is a survey of advanced techniques for the determination of biomolecular structure and will include in-depth discussions of cryo-EM, NMR, and X-ray crystallography as well as other emerging techniques.
Prerequisites: 11:115:403/404 or permission of instructor.
Seminar: Biochemistry Communication (3,3)
Practice in techniques for oral presentation of scientific reports and reviews, based on search of research literature in biochemistry and, where applicable, the student's own research results.
Pre- or corequisites: 11:115:403,404. Open only to senior biochemistry majors.
Research Problems in Biochemistry (BA,BA)
Research projects under the guidance of faculty members.
Prerequisite: Permission of department.
Seminar: Biochemistry and Society (1,1)
Impacts of biochemical advances on society, and vice versa. Social context of major discoveries in biochemistry. Applications of biochemistry: patents, patent law, patent litigation. Student oral presentations and online discussions.
Pre- or corequisite: 11:115:403-404. Open only to senior biochemistry majors.