01:447:216 Analysis of Scientific Literature (Honors) (3) A systematic approach to the reading, analyzing, and understanding of primary literature in genetics; emphasis will be placed on data analysis and experimental design and demystifying the process of reading a scientific journal article. Prerequisites: 01:119:101-102. Highly recommended: 01:694:215. Open only to first-year students and sophomores in the SAS or SEBS honors program.

01:447:245 Introduction to Cancer (3) Introduction to the biological and medical aspects of malignancy.� Prerequisites: 01:119:101-102. Credit not given for both this course and 01:447:495.

01:447:302 Quantitative Biology and Bioinformatics (3) Introduction to the use of computers and computer programming to develop applications for research in genetics and molecular biology. Application topics will include evolutionary genetics, association analysis and genetics mapping, and structural biology. Prerequisite: 01:447:380 or 01:447:384. May be used to fulfill an elective requirement or taken instead of 01:447:315 by students majoring in genetics.

01:447:307-308 Research in Genetics (BA,BA) Laboratory research on an original problem under the direction of a professor.� Prerequisites: 01:447:380 or 384, permission of department, and cumulative grade-point average of 2.8 or better.

01:447:315 Introduction to Research in Genetics (3) Basic principles and methods of research with microbial model systems used in the analysis and manipulation of genes, followed by a research project in molecular genetics.� Prerequisites: 01:119:101-102; and 01:160:161-162, 171, or 01:160:163-164, 171. Credit not given for both this course and 01:694:315. Open only to genetics majors.

01:447:380 Genetics (4)

Introduction to the mechanisms of heredity and evolution. Mechanisms of Mendelian inheritance, meiosis, recombination, gene mutation, and mapping. An introduction to modern biochemical, molecular, and population genetics.

Lec. 3 hrs., rec. 1 hr. Prerequisites: 01:119:101-102 and 01:160:161-162 or 01:160:163-164. Credit not given for both this course and 01:447:384-385 or 11:067:328 or 11:776:305.

01:447:382 Genetics Laboratory (1)

Laboratory to accompany 01:447:380.

Lab. 3 hrs. Pre- or corequisite: 01:447:380 or 384.

01:447:384-385 Genetic Analysis I,II (4,4)

Experimental methods and concepts in genetics, with emphasis on their application to genetic research. Part I covers transmission genetics and breeding analyses, basic molecular genetics, isolation and characterization of mutations, and chromosome structure and function. Part II covers mathematical genetics, recombinant DNA, genomics, and special topics relevant to modern genetic research.

Prerequisites for 01:447:384 are 01:119:101-102 or 01:160:161-162 or 01:160:163-164. Prerequisite for 01:447:385 is 01:447:384. Open only to majors in genetics or by permission of instructor. Credit not given for both this course and 01:447:380 or 11:067:328 or 11:776:305.

01:447:387 Genetics and Evolution: Historical Perspectives (3) In-depth examination of the scientific thought and analysies that have led to important discoveries in genetics, starting with Darwin's The Origin of Species in 1859 to the description of the structure of DNA in 1953; will also examine the conflicts and controversies generated in the scientific and public communities. Prerequisite: 01:447:380 or 384, or equivalent.

01:447:390 General Microbiology (4) Basic principles of microbiology. An introduction to the physiology, morphology, pathogenicity, and genetics of groups of microorganisms and their applications. Lec. 3 hrs., lab. 3 hrs. Prerequisites: 01:119:101-102; 01:160:161-162, 171, and 307. Credit not given for both this course and 11:680:390.

01:447:392 Pathogenic Microbiology (3)

Host/parasite interactions in diseases caused by microorganisms, including pathogenicity, virulence, and immunity. Principles of infection, transmission, and disease control also discussed.

Prerequisite: 01:119:131 or 133 or 01:447:390.

01:447:403,404 Seminar in Genetics (1,1) Student presentations based on special topics selected by the course instructor. Student must take seminar concurrently with the first two semesters of research or advanced independent study.

01:447:405 Honors Seminar in Genetics (1) Assists students with their honors project; emphasis will be on library/internet research and thesis writing. Prerequisites: 01:447:384-385. Open only to seniors in the departmental honors program.

01:447:406-407 Research in Genetics (BA,BA) Research project in the laboratory of a faculty member. Student research plans and results presented in 01:447:403,404.� Prerequisites: 01:447:315, permission of department, and cumulative grade-point average of 2.8 or better. Open only to seniors majoring in genetics.

01:447:408-409 Honors in Genetics (3-6,3-6)

Laboratory research on original problem under the direction of a professor. Written thesis, oral presentation, and defense required.�

Prerequisites: 01:447:315 and permission of department. Open only to seniors majoring in genetics who meet the requirements for the departmental honors program.

01:447:420 Evolutionary Genetics: Humans and Other Primates (3)

Molecular evolution of human and primate genomes; genetic and phenotypic evolution; the genetic basis of being human; primate phylogeny.�

Prerequisites: 01:477:380 or 384 and 01:070:102, 212, or permission of instructor. Credit not given for both this course and 01:070:420.

01:447:451 Genomes (3) Examination of genome structure and function in humans and other organisms. Topics include genome structure and function, the evolution of genomes, and the role of genome analysis in medicine, pharmacology, and agriculture. Prerequisite: 01:447:380 or 384.

01:447:460 Genetics of Compulsive Behavior (3) Discussion of primary literature and other scientific publications that deal with the molecular and genetic basis of compulsive behavior.� Emphasis will be placed on the development of skills for critical thinking and effective writing. Prerequisite: 01:447:380 or 384.

01:447:478,479 Special Topics in Genetics (3,3) Directed readings and discussion of selected topics of special interest in genetics. Prerequisite: 01:447:380 or 384. Topics will vary according to semester and/or instructor.

01:447:480 Topics in Molecular Genetics (3)

Current research topics in microbial and molecular genetics. Lectures, discussions, and critical analyses of journal articles.

Prerequisite: 01:447:380 or 384.

01:447:481 Topics in Human Genetics (3) Genetic aspects of human health and disease. Topics include birth defects, immunogenetics, cytogenetics, metabolic disorders, pattern of inheritance, and genetic counseling.� Prerequisite: 01:447:380 or 384.

01:447:484 Behavioral and Neural Genetics (3)

Discussion of historical and recent research in the application of genetic techniques to the understanding of behavioral and neural differences.

Prerequisite: 01:447:380 or 384. Statistics highly recommended.

01:447:486 Evolutionary Genetics (3) Principles of evolution as revealed in DNA sequences. The effects of natural selection, genetic drift, and speciation on DNA; and the inference of histories from comparative DNA sequence data.� Prerequisite: 01:447:380 or 384.

01:447:489,490 Advanced Independent Study in Genetics (3,3) Advanced independent study on a selected subject conducted under the direction of a faculty member.� Students must produce a written report (thesis, informational website, etc.) and present it to a departmental committee. Pre- or corequisite: 01:447:384.

01:447:495 Cancer (3) Biological and medical aspects of malignancy. Oncogenic viruses, environmental chemical carcinogens, cell growth regulation, tumor immunology, and genetics of cancer. Prerequisite: 01:447:380 or 384. Credit not give for both this course and 01:447:245.

01:447:498 Bacterial Physiology (3)

Bacterial biochemistry with emphasis on integration of metabolic pathways at the level of gene expression and enzymatic activity.

Prerequisites: 01:160:307-308; 01:447:390; or permission of instructor.