16:125:505 (F) Biopolymers (3) Relationship among macromolecular structure, maintenance of tissue shape, and mechanical integrity, particularly in mammalian connective tissues. Emphasis on structural mechanisms related to viscoelastic behavior of collagen and matrix components, as well as rubberlike behavior of elastin. Laboratory demonstrations emphasize relationship of structure and physical properties of structural biomaterials. Silver. Prerequisite: Elementary biochemistry. Recommended: Physical chemistry.

16:125:506 (F) Artificial Implants (3) Structure and properties of materials used to replace soft and hard biological tissues; physical properties of the tissue to be replaced understood through development of structure-property relationships;phase transitions, mechanical and hydrodynamic properties; Processes used to form biomaterials as well as biocompatibility criteria for skin, tendon, bone, cardiovascular, and other applications. Silver

16:125:508 (S) Pathobiology (3) Cellular and tissue reaction to injuries resulting from ischemia, physical forces, and exposure to chemicals, including synthetic and natural polymers. Inflammation, immune reactions, regeneration, and repair. Transplantation of natural and synthetic materials as well as reactions to implanted materials. Silver

16:125:509 (S) Medical Device Development (3) The development of medical devices that employ primarily polymeric materials in their construction. Materials selection, feasibility studies, prototype fabrication, functionality testing, prototype final selection, biocompatibility considerations, efficacy testing, sterilization validation, FDA regulatory approaches, writing of IDE, 510(k), and PMAs, device production, and record keeping. Examples used include materials for cardiovascular stents and for noninvasive measurements of tissue mechanical properties.

16:125:516 (S) Visual Pattern Recognition (3) Patterns are the means by which living organisms and "thinking" machines sense, interpret, classify, and act on information extracted from their surroundings. Recognition is the visual system within the context of information processing in living organisms and computers. Computer vision compared to biological vision. Micheli-Tzanakou. Prerequisites: 01:119:356 and 01:640:244, or equivalent.

16:125:517 (F) Circulatory Dynamics (3) The circulatory system with emphasis on invasive and noninvasive measuring techniques. Topics include measurement of blood pressure and flow in arteries and veins, muscle mechanics, models of the heart, microcirculation, the closed cardiovascular system, and cardiac assist devices. Li

16:125:518 (F) Biometrics: Theory and Applications (3) Theory and applications of biometric characterization of beings, based on physiological/behavioral features and traits, for recognition/identification, identity verification/authentication, and medical diagnosis.
Micheli-Tzanakou

16:125:523 (F) Biomedical Instrumentation Laboratory (3) Practical design of biomedical transducers, electrodes, amplifiers. Operation and performance evaluation of biomedical instruments. Recording, filtering, processing, and analysis of physiological signals. Li

16:125:532 (S) Cytomechanics (3) Mechanical properties and measurements of cells; stress-strain relationships in cells, organelles, and biomatrices, including methods of mechanical measurements. Craelius. Prerequisite: Undergraduate degree in engineering.

16:125:546 (S) Modeling of Biomedical Systems (3) This course is intended to introduce graduate-level biomedical engineering students to methods of modeling and simulating of complex problems in biomedical engineering. Prerequisites: 16:155:507 or equivalent and competence in Matlab. Shinbrot

16:125:564 (S) Advanced Microscopy Laboratory (3) Quantitative and hands-on microscopy with emphasis on the theory of image formation, mechanisms of optical contrast generation, and engineering design of state-of-the-art microscopic instrumentation. Prerequisite: 16:125:431 or equivalent. Boustany

16:125:571 (F) Biosignal Processing (3) Application of basic signal analysis to biological signals and the analysis of medical image. Extensive use of the MATLAB language in example and problems. Semmlow

16:125:572 (S) Biocontrol, Modeling, and Computation (3) Application of control theory to the analysis of biological systems. As foundation for other biomedical engineering courses, topics include (biocontrol) control systems principles; Nyguist and root locus stability analysis; (modeling) Nernst membrane model; action potential; cardiac and vascular mechanics; accommodation and vergence eye movements; saccades; pharmacokinetic models; and numerical solutions to different equations; computer methods using C++; and image processing of biological systems. Shoane

16:125:573 (F) Kinetics, Thermodynamics, and Transport in Biomedicine (3) Biomedical engineering core course intended for those seeking familiarity with the effects of, and tools to deal with, fluid, multiphase, chemical, and thermal transport and kinetics problems in biological systems. Shinbrot

16:125:574 (S) Biomaterials and Biomechanics (3) Problems in continuum mechanics; application in biomechanics. Shreiber

16:125:575 (S) Topics in Biomedical Engineering (3)

16:125:582 (S) Nano and Microengineered Biointerfaces (3) Methods and mechanisms for engineering interfaces on the nano- and micro-scale. Synthesis and fabrication, including: 1) preparing substrates that have nano- and/or micro-scale features; and 2) creating nano- and/or micro-scale substrates. The substrate materials discussed will typically consist of ceramics, polymers, and metals whereas the biological systems will comprise cells, genes, and ligands. Uhrich, Fabris

16:125:583 (F) Biointerfacial Characterization (3) Physical, chemical, and biological methods of characterizing biointerfaces, broadly defined. Biointerfaces considered will include conventional interfaces of biomolecules (e.g., proteins) on artificial substrates, as well as interfaces of submicroscopic and nanoscale particles with biomolecules and living cells. Moghe

16:125:584 (S) Integrative Molecular and Cellular Bioengineering (3) Integration of engineering and mathematical principles with molecular and cell biology entities for the understanding of physiology and solution of medical problems. Roth

16:125:586 (S) Stem Cell Biology and Bioengineering (3) The science behind stem cell research, its implications and potential, and the ethical and social issues it raises.
Prerequisite: Background in developmental biology, biochemistry, molecular biology, and/or biomedical engineering.

16:125:589 (F) Biomedical Applications of Microelectromechanical Systems and Bionanotechnology (3) Micro- and nanoengineering design and fabrication, material compatibility with biological systems, and cellular interaction at the interface. Zahn

16:125:590 (S) Drug Delivery Fundamentals and Applications (3) The engineering of novel pharmaceutical delivery systems based on fundamental understanding of physiologic delivery barriers and the development of compatible and tailored materials. Roth

16:125:601 (F) Engineering Ethics and Seminar (1) The history of ethics in scientific research; case studies.
Shinbrot

16:125:602 (S) Engineering Writing and Seminar (1) Technical writing, including strategic decisions concerning types of writing for successful papers and proposals. Shinbrot

16:125:603,604 Topics in Advanced Biotechnology (1,1) Yarmush

16:125:607,608 (F/S) Preparing Future Faculty I,II (1,1) Required of all second-year doctoral students. Topics include learning styles, teaching tools, and methodology.� In the second semester, students will intern in biomedical engineering introductory laboratories. Langrana

16:125:615 (F) Advanced Topics in Brain Research (3) Advanced study of current areas of brain research. Topics include information processing in the brain, pattern recognition in different sensory modalities, advanced techniques of diagnosing different system disorders, and data recording and techniques of analysis. Topics vary depending on student interest and faculty availability. Papathomas

16:125:618 (S) Innovation and Entrepreneurship for Science and Technology (3) Practical framework for identification and commercialization of technology-intensive commercial opportunities; need/opportunity analysis, competitive analysis, legal protection, marketing, financing, resourcing, and communication of the venture. Yarmush, Maguire

16:125:620 Neural Networks and Neurocomputing (3) Classical theories such as the Perceptron; LMS algorithm; the Boltzmann machine; Hopfield nets; back propagation; associative neurons; as well as adaptive algorithms, such as the ALOPEX algorithms, examined in detail. Different applications and current literature examined and discussed. Micheli-Tzanakou

16:125:621-627 Special Problems in Biomedical Engineering (BA,BA)

16:125:628 (S) Clinical Practicum (1) Students are introduced to clinical aspects of biomedical engineering by attending regular grand rounds given by clinical specialists from medical schools and hospitals. Selected demonstrations of clinical procedures with applications of modern technology. Yarmush

16:125:699 Nonthesis Study (BA) For Plan B master's degree students.

16:125:701,702 (F/S) Research in Biomedical Engineering (BA,BA) Students conduct research in their areas of specialty under the direction of a faculty adviser.