(F) Biochemistry (3)
Modern concepts of protein biochemistry and metabolism for first-year Ph.D. students.
Winkelmann. Prerequisite: One year organic chemistry. Corequisite: 16:115:502.
(F) Biochemistry (Molecular Biology) (3)
Modern concepts of nucleic
acid biochemistry in replication, recombination, transposition, transcription,
splicing, and translation for first-year Ph.D. students.
Gabriel. Prerequisite: One year organic chemistry. Corequisite: 16:115:501.
General Biochemistry (4,4)
A one-year survey of modern biochemistry. Structure and functions of biochemical materials including proteins, carbohydrates, nucleic acids, and lipids. Metabolism, including metabolic integration. Information processing and control of gene expression. Computer laboratory in structural biology included.
Kahn, van Es. Prerequisite: One year of organic chemistry.
(S) Proteins and Enzymes (3)
Assay and purification of enzymes and other proteins. Kinetics, chemical modification, and site-directed mutagenesis as tools in understanding structure-function relationships and enzyme mechanisms. Selected examples of posttranslational modification. General theories and specific examples of the chemical basis of enzymic catalysis.
Chase. Prerequisite: 16:115:501 or equivalent.
(F) Molecular Biology and Biochemistry (3,3)
First semester: structure and
function of proteins, nucleic acid structure, catalysis of biochemical
reactions, glycolysis, oxidative phosphorylation, photosynthesis, properties of
membranes, signal transduction, intermediary metabolism. Second semester: recombinant
DNA approaches, DNA replication, mutability, recombination, repair, and
transposition, transcription, posttranscriptional processing, translation, gene
Deis, Brill. Prerequisite: One year organic chemistry. These courses recommended for students outside the program in biochemistry.
Biochemical Separations (3)
Basic theory and practice of separating biological molecules. Methods include chromatography, centrifugation, electrophoresis, ultrafiltration, and general methods of extraction and purification of proteins, nucleic acids, carbohydrates, and other biological molecules.
Prerequisite: 11:115:313 or 11:115:413.
(F) Ethical Scientific Conduct (1)
Introduction to ethical issues of scientific investigation, including intellectual property, plagiarism, conflict of interest, human and animal subjects, and record keeping.
Intended for Ph.D. candidates in the biomedical sciences. This course is designed to meet NIH requirements.
Advanced Studies in Biochemistry (BA,BA)
Independent library and laboratory research into special aspects of biochemistry arranged under the supervision of faculty members in any of the participating groups.
Seminar in Biochemistry (1,1)
Quantitative Problems in Biological Sciences (2)
Provides hands-on experience in solving quantitative problems in a
workshop format typically encountered in current biological sciences
research. Practical applications to laboratory experiments will be
Corequisites: 116:115:501 and 502.
Special Topics in Biochemistry (BA)
Occasional special course on a new or developing topic in
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Student Research Seminar I (.5, .5, .5, .5)
Research in Biochemistry (BA,BA)