16:115:556 Ethical Scientific Conduct (1) Introduction to ethical issues of scientific investigation, including intellectual property, plagiarism, conflict of interest, human and animal subjects, and record keeping.

16:720:507 Advanced Pharmaceutics (3) Application of physical-chemical principles to the study and evaluation of pharmaceutical systems: solubility phenomena, equilibria, complexation, phase transitions, and pharmaceutical stability, and the fundamentals of pharmacokinetics. Sinko. Prerequisites: Physical chemistry and associated math requirements.

16:720:509 Advanced Pharmacokinetics/Dynamics (3) Methods, models, and equations used in pharmacokinetics along with their physicochemical and physiological assumptions and limitations. Graphical computer methods of data analysis and applications of pharmacokinetic-pharmacodynamic modeling of pharmacologic responses in biological systems. Kong. Prerequisites: Ordinary differential equations (or equivalent) and pharmacokinetics.

16:720:523 Dermaceutics (3) Design of topical drug delivery systems; theoretical and practical considerations in development of topical disperse systems; skin permeation of drugs and its optimization; dermatologic and cosmetic applications. Michniak-Kohn. Prerequisite: 16:720:507.

16:720:527 Biopharmaceutics of Orally Administered Drugs (3) Covers the biopharmaceutical sequence of events that occur after the oral administration of drugs starting from mechanisms of uptake/secretion through delivery to systemic circulation.

16:720:540 Independent Research Proposal (3) Develop a written research proposal using the standard HHS/NIH format as part of the Ph.D. degree requirements. Proposal is evaluated as to its originality, scientific merit, and quality. Enrollment limited to Ph.D. candidates with approval of their adviser.

16:720:549 (S) Genetically Engineered Drug Delivery Systems (3) Genetically engineered therapeutic systems; emphasis on biopolymers (recombinant polymers), viruses, and stem cells. Hatefi

16:720:550 Nanotechnology-Based Drug Delivery (3) Materials and processes for novel drug delivery systems; synthesis of biocompatible nanoparticles for health care; product design, current products, and regulatory issues.

16:720:601,602 Seminar in Pharmaceutical Science (1,1) Presentation and discussion of recent developments in the pharmaceutical sciences.

16:720:609 Membrane Transporters in Drug Disposition (3) Drug transporters, their roles in human physiology and diseases, and principles of drug transport and its associated techniques. You

16:720:610,611 Independent Study in Pharmaceutical Science (BA,BA) Independent library and/or laboratory research into special aspects of pharmaceutical science; arranged under the supervision of a specific faculty member. No more than 3 credits may be taken as part of a student's program.

16:720:614 Molecular and Cellular Pharmaceutics (3) Cellular response to drugs in different dosage forms and drug delivery systems. Transport through biological barriers of different drug delivery forms, the main cellular signaling pathways triggered by various drugs and drug formulations, types of cell death induced by various types of modern drugs, cellular adaptation to drug exposure, cellular mechanisms of multidrug resistance, interaction between drugs and DNA. Principles of pharmacogenomics and pharmacogenetics. Minko

16:720:701,702 Research in Pharmaceutical Science (BA,BA)