16:155:501 (F) Advanced Transport Phenomena I (3) Momentum transport processes in laminar- and turbulent-flow systems. Development and application of steady and unsteady boundary-layer processes, including growth, similitude principles, and separation. Potential flow theory coupled with viscous dissipation at boundaries. Momentum transport in fixed- and fluid-bed exchangers and reactors. Prerequisite: Undergraduate transport phenomena.

16:155:502 (S) Advanced Transport Phenomena II (3) Energy balances derived from first- and second-law approaches to open systems, with reaction. Conduction in fluids and solids, both steady and unsteady examples. Convection in laminar- and turbulent-flow systems. Diffusion and its treatment in stagnant and flowing media. Two-phase systems, coupled reaction, and mass transfer. Interphase transport. Prerequisite: Permission of instructor.

16:155:507 (F) Analytical Methods in Chemical and Biochemical Engineering (3) Analytical solutions to deterministic mathematical models encountered in chemical and biochemical engineering, including environmental and safety systems. Emphasis is on purpose, philosophy, classification, development, and analytical solutions of models occurring in transport phenomena, thermochemical, and reactor systems. Prerequisites: Undergraduate differential and integral calculus and differential equations or permission of the graduate director.

16:155:508 (F) Chemical Engineering Analysis (3) Mathematical modeling and simulation of chemical and biochemical systems; numerical methods. Solution of ordinary and partial differential equations. Statistical methods of linear and nonlinear regression analysis; optimization methods. Extensive use of digital computers. Prerequisite: Undergraduate or graduate degree in chemical engineering or in the biological or physical sciences.

16:155:511 (F) Advanced Chemical Engineering Thermodynamics (3) Basic principles of classical chemical thermodynamics. Chemical and physical equilibria and their relationships in simple and reactive systems. Estimation and correlation of thermodynamic functions, applications of thermodynamic principles to transport and rate processes. Irreversible and statistical thermodynamic topics also introduced. Prerequisite: Undergraduate or graduate degree in engineering or chemistry.

16:155:512 Advanced Chemical Engineering Molecular Thermodynamics (3) Statistical ensembles; ideal and nonideal gases; liquids; distribution function theories; Ornstein-Zernike equation; computer simulation methods; perturbation theories; engineering semiempirical equations of state; applications to chemical engineering systems. Prerequisite: 16:155:511 or equivalent.

16:155:513 (F) Fundamentals of Nanoscale Thermodynamics and Transport (3) Introduction to theoretical and multiscale simulation methods applied to thermodynamics and transport in nanoscale chemical and biological systems, including nanoparticles and nanocomposites, porous materials, nanostructured colloids and surfaces, self-assembled surfactant and polymeric systems, lipid bilayers, and cell membranes. Prerequisites: Basic courses on thermodynamics and transport or permission of instructor.

16:155:514 (S) Kinetics, Catalysis, and Reactor Design (3) Principles of applied chemical kinetics, reaction mechanisms and rate laws, and engineering design of reactor vessels. Applications to homogeneous and heterogeneous process reaction systems with internal, transphase, and external mass transfer. Noncatalytic gas-solid reaction and gas-liquid absorption with reaction. Micromixing and macromixing in reactor systems. Prerequisites: 16:155:501 and 507, or equivalent.

16:155:517 Advanced Process Control (3) Review of analysis and design of feedback control systems. Advanced process control systems. Control systems for multivariable processes. Process control systems, using computers and artificial intelligence techniques. Intelligent control laboratory. Prerequisite: Process control or permission of instructor.

16:155:518 (S) Process Systems Engineering (3) Key issues in process synthesis and design and process operations. Mathematical modeling, algorithmic development, and optimization. Computer-aided tools. Applications: planning and scheduling of batch/continuous processes, energy integration in industrial plants, and uncertainty evaluation and consideration in plant design. Case studies. Prerequisite: Undergraduate engineering design.

16:155:531 (F) Biochemical Engineering (3) Integration of the principles of chemical engineering, biochemistry, and microbiology. Development and application of biochemical engineering principles. Analysis of biochemical and microbial reactions. Prerequisites: Degree or option in biochemical engineering, or (01:115:301 or 11:115:301) and 01:119:390, or equivalent.

16:155:532 (F) Topics in Biochemical Engineering (3) Advanced course devoted to current topics of interest in biochemical and enzyme engineering. Topics include production, isolation, and purification of enzymes; downstream processing; design and analysis of bioreactors; bioprocess economics; modeling, optimization; and scale-up of biochemical systems. Content and format may vary from year to year. Prerequisite: 16:155:531.

16:155:533 (S) Bioseparations (3) Fundamental problems of separation processes important to the recovery of products from biological processes. Topics include membrane filtration centrifugation, chromatography, extraction, electrokinetic methods. Emphasis on protein separations. Prerequisite: Permission of instructor.

16:155:541 Pharmaceutical Materials Engineering (3) Applications to designing and optimizing pharmaceutical processes and products. Production, characterization, and usage of pharmaceutical materials. The relationship between pharmaceutical materials and pharmaceutical products. Glasser. Prerequisite: Undergraduate degree in chemical engineering or permission of instructor.

16:155:544 Pharmaceutical Organic Nanotechnology--Drug Delivery (3) An introduction to organic nanotechnology and its application to engineering pharmaceutical delivery systems. Industrial and emergent pharmaceutical examples, including nanoparticle and nanocomposite synthesis. Prerequisite: Permission of instructor.

16:155:545 Pharmaceutical Process Design I: Synthesis, Separations, and Sterile Processing (3) An introduction to synthesis, separations, and sterile processing and their applications to designing and optimizing pharmaceutical processes. Industrial pharmaceutical examples, including separation, distillation, crystallization, filtration, lyophilization, and drying processes. Prerequisite: Permission of instructor.

16:155:546 Pharmaceutical Process Design II: Unit Operations (3) An introduction to the essential operations used in the manufacture of pharmaceutical products. The pharmaceutical product life cycle, variability, and testing; and specifications of pharmaceutical ingredients. Unit operations including blending, granulation, fluidized bed operations, milling, capsule filling, compaction, tablet coating, and other processes will be addressed. How the output of one process is the input to the next process, and how deviations can cascade along the production sequence until they cause process failures. Design, scale-up, troubleshooting, and optimization. Prerequisite: Permission of instructor.

16:155:547 Statistical Analysis and Design of Pharmaceutical Operations (3) An introduction to statistical analysis and experimental design methods and their applications to designing and optimizing pharmaceutical processes. Classic statistical concepts and methods using pharmaceutical examples including product/process development scenarios, routine in-process and finished product testing, and failure investigations. Regulatory requirements for test of samples, sampling plans, tablet and capsule assay, content uniformity, hardness, friability, dissolution, and bioavailability tests. Prerequisite: Permission of instructor.

16:155:548 Advanced Topics in Pharmaceutical Engineering (3) Content and format may vary from year to year. Thermochemical process safety; physiochemical methods at the bulk/dosage form interface; and surface chemistry of crystallization, extraction, and adsorption.

16:155:549 Advanced Engineering Pharmaceutical Kinetics, Thermodynamics, and Transport Processes (3) Thermodynamics of pharmaceutical systems, phase diagram, phase equilibrium, and chemical equilibrium; diffusive and convective transport in pharmaceutical processes; chemical and pharmacokinetics and reaction engineering of pharmaceutical systems. Chiew. Prerequisite: Undergraduate degree in chemical engineering or permission of instructor.

16:155:550 Computational Methods for Pharmaceutical Nanomaterials (3) An introduction to organic nanotechnology and its application to manufacturing drug products, using industrial pharmaceutical examples, including nanoparticle and nanocomposite synthesis. Tomassone. Prerequisite: Undergraduate degree in chemical engineering or permission of instructor.

16:155:551 Polymer Science and Engineering I (3) Physical and chemical structure of polymers; morphology of polymer crystals; microscopic texture. Mechanical properties; influence of orientation; effects of temperature and environment; engineering applications.

16:155:552 Polymer Science and Engineering II (3) Emphasis on a modern treatment of polymers, including statistical mechanics scaling concepts and polymer properties and characterization. Prerequisite: 16:155:551.

16:155:561 Applied Surface Chemistry (3) Phenomena and processes relevant to chemical engineering characterized by large interfacial area relative to phase volume. Fundamental principles of surface chemistry and physics, such as interfacial tension and pressure. Study of colloidal state and colloidal particles. Theories of electrical double layer and stability of suspensions. Application of theory to important processes such as foaming, emulsification, detergency, adhesion, ore flotation, and rate processes controlled at a phase interface, including nucleation and crystallization. Prerequisite: Undergraduate or graduate degree in chemical engineering or in the biological or physical sciences.

16:155:571 Sustainable, Renewable, and Clean Energy (3) Engineering perspectives on conventional energy resources, energy challenges, and efforts on the development of sustainable, clean, and renewable energy sources. Fundamental energy science topics that are the bases for various energy systems.

16:155:588,589 (F) Special Problems in Chemical Environmental Engineering (3,3) Natural water bodies described by the techniques developed for chemical and biochemical reactor analysis. Physical transport, interfacial exchanges, and biochemical reactions. Examples drawn from reaeration processes, surface water temperature and energy balances, and stochastic variations in stream discharge. Prerequisites: 16:155:501, 502, or equivalent.

16:155:601,602 Chemical Engineering Graduate Seminar (0,0) Graduate students make a formal presentation on their independent study and/or research. Outside speakers also are invited.

16:155:603,604 Topics in Advanced Biotechnology (1,1) Oral presentations and discussions of current literature in biotechnology. Topics selected from the following: tissue, genetic, and protein engineering; growth control; receptor signaling; immunotechnology; neurotechnology; and others. Prerequisite: Permission of instructor.

16:155:605 Teaching in the Engineering Curriculum (N1,N1) Training on learning style, effective teaching techniques, presentation techniques, teamwork, and professional skills.

16:155:701,702 Research in Chemical and Biochemical Engineering (BA,BA)