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11:115:301
Introductory Biochemistry (3)
The chemistry and metabolism of proteins, carbohydrates, lipids, nucleic acids, and other biologically important compounds.
Prerequisites: 01:160:209 or 307-308 or 315-316.
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11:115:313
Introductory Biochemistry Laboratory (1)
Techniques used in research, clinical, and food laboratories, including tests of biological materials, methods of separations, and determinations of enzyme activities.
Lab. 3 hrs. Pre- or corequisite: 11:115:301 or 403.
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11:115:403,404
General Biochemistry (4,3)
A comprehensive survey of the chemistry and metabolism of biological compounds, including proteins, polysaccharides, lipids, and nucleic acids. Enzyme kinetics, bioenergetics, organelles, and cellular organization. Expression and processing of biological information, including DNA replication; transcription into RNA; translation into protein, regulation, and recombinant DNA techniques. A detailed computer laboratory study of structural biology, including protein and nucleic acid three-dimensional structures and the interactions between these and ligands.
Prerequisites: 01:160:307-308 or 315-316 with grades of C or better.
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11:115:406
Problem Solving in Biochemistry (1.5)
Modern instrumentation and analytical techniques used in biochemistry research. Observation of experiments followed by discussion of techniques and problems.
Rec. 1 hr., lab. 1.5 hrs.
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11:115:412
Protein and Enzyme Chemistry (3)
Assay and purification of enzymes and other proteins. Chemical modification, site-directed mutagenesis, and enzyme kinetics as tools in understanding structure-function relationships and enzyme mechanisms. Mechanisms of selected enzymes.
Prerequisites: 11:115:403 and 413, or equivalents.
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11:115:413,414
Experimental Biochemistry (3,2.5)
Isolation, characterization, and quantitative determination of biological compounds. Spectrophotometric and titrimetric analyses; chromatography and gel electrophoresis; high performance liquid chromatography. Isolation and characterization of enzymes, nucleic acids, and lipids. Graphing and statistical treatment using computers.
Lec. 1 hr. (for 413), 55-min. (for 414), lab. 4.5 hrs (for both 413 and 414). Corequisites: 11:115:403,404. Recommended: 01:447:380.
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11:115:421
Biochemistry of Cancer (3)
DNA damage/repair mechanisms; oncogenes/tumor suppressor genes; signaling pathways; apoptosis/cell death; the cell cycle; metastasis-cell, cell contact, and protease activation; tumor growth and angiogenesis; genetic events; genetic polymorphisms; chemical carcinogenesis; chemotherapeutic targeting.
Prerequisites: 11:115:403-404.
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11:115:422
Biochemical Mechanisms of Toxicology (3)
General principles and mechanisms of biochemical toxicology, including pharmacokinetics and pharmacodynamics. Examples of metabolism of industrial compounds, organic agrichemicals, and carcinogens.
Prerequisites: 01:119:101-102, 01:160:307-308 or 315-316. Pre- or corequisites: 11:115:403,404 or equivalent. Recommended: 01:146:356 or equivalent.
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11:115:428
Homology Modeling of Proteins (3)
Computer construction of models of the three-dimensional structure of proteins, based on known structures of proteins with related sequences. Interpretation and prediction of function based on the modeled structure.
Prerequisite: 11:115:403.
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11:115:433
Special Topics in Biochemistry (1)
Self-paced computer tutorials in structural biochemistry; designed to supplement courses in molecular biosciences.
Prerequisite: 11:115:403.
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11:115:434
Molecular Toxicology (1.5)
Principles and methodologies of toxicology, at the organismal and molecular levels.
One 80-min. lec. Prerequisites: A course in biochemistry, a course in toxicology, laboratory experience.
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11:115:436
Molecular Toxicology Laboratory (2.5)
Techniques currently applied in public and private toxicology laboratories.
One 80-min. pre-lab., one 3-hr. lab. Corequisite: 11:115:434.
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11:115:452
Biochemical Separations (3)
Basic theory and practice of separating biological molecules. Chromatography, centrifugation, electrophoresis, ultrafiltration, and general methods of extracting and purifying proteins, nucleic acids, carbohydrates, and other biological molecules.
Prerequisites: 11:115:301 or 403, 11:115:313 or 413.
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11:115:491,492
Seminar: Biochemistry Communication (1,1)
Practice in techniques for oral presentation of scientific reports and reviews, based on search of research literature in biochemistry and, where applicable, the student's own research results.
Pre- or corequisites: 11:115:403,404. Open only to senior biochemistry majors.
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11:115:493,494
Research Problems in Biochemistry (BA,BA)
Research projects under the guidance of faculty members.
Prerequisite: Permission of department.
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11:115:495,496
Seminar: Biochemistry and Society (1,1)
Impacts of biochemical advances on society, and vice versa. Social context of major discoveries in biochemistry. Applications of biochemistry: patents, patent law, patent litigation. Student oral presentations and online discussions.
Pre- or corequisite: 11:115:403-404. Open only to senior biochemistry majors.
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