16:718:523
Drug Metabolism (2)
Selected papers from the primary literature pertaining to the
metabolism of foreign chemicals. Properties and regulation of foreign
compound-metabolizing enzymes in microorganisms, plants, insects, lower
mammals, and humans. Significance of these enzymes for the metabolism
and action of foreign chemicals and endogenous substrates in intact
cells and organisms.
Conney, Kauffman. Prerequisite: Permission of instructor.
|
16:718:565,566
Advanced Problems in Pharmacology (BA,BA)
Independent research with a faculty member on some aspect of a research problem. With minimum supervision, students are expected to analyze, interpret, and report the experimental data.
Prerequisites: Permission of graduate director and instructor.
|
16:718:574
Neuropharmacology (2)
Mechanisms of synaptic transmission in the nervous system, role of
voltage- and ligand-gated ion channels, and G-protein coupled receptors
in information transmission. Regulation of the synthesis, storage,
release, and destruction of neurotransmitters.
Meiners, Sonsalla. Prerequisite: Permission of instructor.
|
16:718:575
Signal Transduction (2)
Biology, pharmacology, and molecular biology of the cell cycle.
Ryazanov. Prerequisite: Permission of instructor.
|
16:718:581
Hormones and Their Receptors (2)
Modern theories of hormone action at the cellular and molecular levels. Familiarity with biochemistry, cell biology, and molecular biology is advisable.
Chen, Fondell. Prerequisite: Permission of instructor.
|
16:718:582
Pharmacology of Ion Channels and Transporters (2)
Ion channels and transporters at
the cellular and molecular levels. Background in cell biology recommended.
Prerequisite: Permission of instructor.
|
16:718:600
Cancer Pharmacology (2)
Mechanisms of actions of antitumor agents, design and discovery of anticancer drugs, and discovery of basic signaling mechanisms that constitute the targets of molecules used for cancer therapy. Novel strategies for cancer drug discovery.
Jin, Liu. Prerequisite: Permission of instructor.
|
16:718:601
Genetics in Pharmacology (2)
Genetic strategies in understanding drug mechanisms and in the search for new pharmaceutically active agents. Some familiarity with genetics advisable.
Lobel, Walworth. Prerequisite: Permission of instructor.
|
16:718:602
Seminar in Pharmacology (1)
Faculty and student presentations.
|
16:718:603
Genomics in Cancer Therapeutics (3)
The application of genomics for target discovery using DNA microarrays, target identification for cancer therapeutics based on abnormalities in the cancer cell versus the normal cell, and noninvasive imaging of tumors. Gene therapy and differentiation therapy strategies for attacking the tumor cell based on knowledge gained from functional genomics of the tumor cell.
Banerjee. Prerequisite: Permission of instructor.
|
16:718:605
Drug-Target Interactions (2)
Basic principles of the secondary and tertiary structures of nucleic acids used to explore aspects of nucleic acid biology such as protein-nucleic acid interactions, RNA-catalyzed reactions, and nucleic acid pharmacology.
Gartenberg, Studitsky. Prerequisite: Permission of instructor.
|
16:718:680
Cellular and Molecular Pharmacology: Principles of Drug Action and Targeting (3)
Molecular basis of pharmacologic selectivity, drug targets, adaptive responses to drugs, disposition of drugs, and genetic and molecular approaches to drug therapy.
Pilch. Prerequisites: Permission of graduate director and instructor.
|
16:718:701,702
Research in Pharmacology (BA,BA)
|
