16:125:505 (F) Biopolymers (3) Relationship among macromolecular structure, maintenance of tissue shape, and mechanical integrity, particularly in mammalian connective tissues. Emphasis on structural mechanisms related to viscoelastic behavior of collagen and matrix components, as well as rubberlike behavior of elastin. Laboratory demonstrations emphasize relationship of structure and physical properties of structural biomaterials. Silver. Prerequisite: Elementary biochemistry. Recommended: Physical chemistry.

16:125:508 (S) Pathobiology (3) Cellular and tissue reaction to injuries resulting from ischemia, physical forces, and exposure to chemicals, including synthetic and natural polymers. Inflammation, immune reactions, regeneration, and repair. Transplantation of natural and synthetic materials as well as reactions to implanted materials. Silver. Prerequisite: 11:115:301 or equivalent.

16:125:512 (S) Fundamentals of Computed Tomography (3) Image restoration and enhancement techniques, convex projections, pseudo inverse, back projection, simplex methods, least mean square error, constrained solutions, nonlinearities. Applications include X-ray, ultrasound, NMR, and optical medical imaging systems.

16:125:513 (S) Visual Research and Instrumentation (3) Control system analysis of human visual systems and survey of instrumentation used. Topics include anatomy of the visual system; triad: accommodation, vergence, and pupil; saccadic and pursuit eye movements. Shoane. Prerequisite: 14:332:345 or equivalent.

16:125:516 (S) Visual Pattern Recognition (3) Patterns are the means by which living organisms and "thinking" machines sense, interpret, classify, and act on information extracted from their surroundings. Recognition is the visual system within the context of information processing in living organisms and computers. Computer vision compared to biological vision. Micheli-Tzanakou. Prerequisites: 01:119:356 and 01:640:244, or equivalent.

16:125:517 (F) Circulatory Dynamics (3) The circulatory system with emphasis on invasive and noninvasive measuring techniques. Topics include measurement of blood pressure and flow in arteries and veins, muscle mechanics, models of the heart, microcirculation, the closed cardiovascular system, and cardiac assist devices. Li

16:125:518 (F) Biometrics: Theory and Applications (3) Theory and applications of biometric characterization of beings, based on physiological/behavioral features and traits, for recognition/identification, identity verification/authentication, and medical diagnosis.
Micheli-Tzanakou

16:125:520 (S) Neuroelectric Systems (3) Introduction to function and models of the nervous system; generator and action potentials; conduction in nerve fibers and across synaptic junctions; analysis of sensory and neuromuscular systems; EEG and EKG waveforms. Micheli-Tzanakou. Prerequisites: 16:332:505 and general physiology.

16:125:523 (F) Biomedical Instrumentation Laboratory (3) Practical design of biomedical transducers, electrodes, amplifiers. Operation and performance evaluation of biomedical instruments. Recording, filtering, processing, and analysis of physiological signals. Li

16:125:532 (S) Cytomechanics (3) Mechanical properties and measurements of cells; stress-strain relationships in cells, organelles, and biomatrices, including methods of mechanical measurements. Craelius. Prerequisite: Undergraduate degree in engineering.

16:125:546 (S) Self-Assembly Pattern (3) For engineers who seek familiarity with and tools to analyze self-assembly of polymers, proteins, cells, and multicellular systems encountered in subfields ranging from tissue replacement therapies to polymeric drug delivery systems. Shinbrot

16:125:562 Medical Imaging Analysis (3) Models of image formation, part and process segmentation and recognition. Specialized models of living organisms. Structural and statistical models of form; reasoning and interpretation models of functions. Medical diagnosis. Artificial intelligence and computational biology. Metaxas

16:125:571 (F) Biosignal Processing (3) Application of basic signal analysis to biological signals and the analysis of medical image. Extensive use of the MATLAB language in example and problems. Semmlow

16:125:572 (S) Biocontrol, Modeling, and Computation (3) Application of control theory to the analysis of biological systems. As foundation for other biomedical engineering courses, topics include (biocontrol) control systems principles; Nyguist and root locus stability analysis; (modeling) Nernst membrane model; action potential; cardiac and vascular mechanics; accommodation and vergence eye movements; saccades; pharmacokinetic models; and numerical solutions to different equations; computer methods using C++; and image processing of biological systems. S. Dunn

16:125:573 (F) Kinetics, Thermodynamics, and Transport in Biomedicine (3) Biomedical engineering core course intended for those seeking familiarity with the effects of, and tools to deal with, fluid, multiphase, chemical, and thermal transport and kinetics problems in biological systems. Shinbrot

16:125:574 (S) Biomaterials and Biomechanics (3) Foundation in basic engineering statistics, dynamics, and strength materials expected. These engineering concepts are applied to biologic tissues and the mechanics of musculoskeletal systems under both normal and pathologic conditions. Issues ranging from basic biocompatibility to engineered tissue replacements will be discussed. Shreiber

16:125:575 (S) Topics in Biomedical Engineering (3)

16:125:581 (S) Mammalian Physiology (3) Focus on the physiological parameter to be controlled and how the different systems (nervous, endocrine, respiratory, cardiovascular, renal, gastrointestinal) contribute to homeostasis of that particular parameter. Cai. Prerequisites: Undergraduate biology and physiology.

16:125:582 (S) Nano and Microengineered Biointerfaces (3) Methods and mechanisms for engineering interfaces on the nano- and micro-scale. Synthesis and fabrication, including: 1) preparing substrates that have nano- and/or micro-scale features; and 2) creating nano- and/or micro-scale substrates. The substrate materials discussed will typically consist of ceramics, polymers, and metals whereas the biological systems will comprise cells, genes, and ligands. Uhrich

16:125:583 (F) Biointerfacial Characterization (3) Physical, chemical, and biological methods of characterizing biointerfaces, broadly defined. Biointerfaces considered will include conventional interfaces of biomolecules (e.g., proteins) on artificial substrates, as well as interfaces of submicroscopic and nanoscale particles with biomolecules and living cells. Moghe

16:125:584 (S) Integrative Molecular and Cellular Bioengineering (3) Integration of engineering and mathematical principles with molecular and cell biology entities for the understanding of physiology and solution of medical problems. Roth

16:125:586 (S) Stem Cell Biology and Bioengineering (3) The science behind stem cell research, its implications and potential, and the ethical and social issues it raises.
Cai, Herrup. Prerequisite: Background in developmental biology, biochemistry, molecular biology, and/or biomedical engineering.

16:125:601 (F) Journal Club and Seminar (1) Each fall semester all BME students are expected to attend the Journal Club and Seminar Series. Every other week, students will review the current literature. On the alternating weeks, students will hear speakers from within and outside the Rutgers/UMDNJ community present their research results.
Shinbrot

16:125:602 (S) Survival Skills and Seminar (1) Required of all BME students each spring. Meets every other week.�� Moghe

16:125:607,608 (F/S) Preparing Future Faculty I,II (1,1) Required of all second-year doctoral students. Topics include learning styles, teaching tools, and methodology.� In the second semester, students will intern in BME introductory laboratories. Chabal

16:125:615 (F) Advanced Topics in Brain Research (3) Advanced study of current areas of brain research. Topics include information processing in the brain, pattern recognition in different sensory modalities, advanced techniques of diagnosing different system disorders, and data recording and techniques of analysis. Topics vary depending on student interest and faculty availability. Papathomas

16:125:620 Neural Networks and Neurocomputing (3) Classical theories such as the Perceptron; LMS algorithm; the Boltzmann machine; Hopfield nets; back propagation; associative neurons; as well as adaptive algorithms, such as the ALOPEX algorithms, examined in detail. Different applications and current literature examined and discussed. Micheli-Tzanakou

16:125:621-627 Special Problems in Biomedical Engineering (BA,BA)

16:125:628 (S) Clinical Practicum (1) Students are introduced to clinical aspects of biomedical engineering by attending regular grand rounds given by clinical specialists from medical schools and hospitals. Selected demonstrations of clinical procedures with applications of modern technology. Micheli-Tzanakou

16:125:699 Nonthesis Study (BA) For Plan B master's students.

16:125:701,702 Research in Biomedical Engineering (BA,BA) Students conduct research in their areas of specialty under the direction of a faculty adviser.