16:115:501
(F) Biochemistry (3)
Modern concepts of protein biochemistry and metabolism for first-year Ph.D. students.
Winkelmann. Prerequisite: One year organic chemistry. Corequisite: 16:115:502.
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16:115:502
(F) Biochemistry (Molecular Biology) (3)
Modern concepts of nucleic acid biochemistry and metabolism for first-year Ph.D. students.
Kozak. Prerequisite: One year organic chemistry. Corequisite: 16:115:501.
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16:115:508
(S) Proteins and Enzymes (3)
Assay and purification of enzymes and other proteins. Kinetics, chemical modification, and site-directed mutagenesis as tools in understanding structure-function relationships and enzyme mechanisms. Selected examples of posttranslational modification. General theories and specific examples of the chemical basis of enzymic catalysis.
Chase. Prerequisite: 16:115:501 or equivalent.
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16:115:511,512
(F) Molecular Biology and Biochemistry (3,3)
First term: structure and function of proteins, nucleic acid structure, catalysis of biochemical reactions, glycolysis, oxidative phosphorylation. Recombinant DNA approaches, DNA replication, mutability, recombination, repair, and transposition. Second term: transcription, posttranscriptional processing, translation, gene regulation, photosynthesis, properties of membranes, signal transduction, intermediary metabolism.
Prerequisite: One year organic chemistry. These courses recommended for students outside the program in biochemistry.
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16:115:533
(F) Physical Biochemistry (3)
Protein folding used as theme to discuss principles of physical chemistry of macromolecules of biochemical importance. Specific aspects of thermodynamics and kinetics are related to biopolymers. Spectroscopic techniques, including circular dichroism, as well as other biophysical methods.
Kahn. Prerequisites: Biochemistry, physical chemistry.
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16:115:552
Biochemical Separations (3)
Basic theory and practice of separating biological molecules. Methods include chromatography, centrifugation, electrophoresis, ultrafiltration, and general methods of extraction and purification of proteins, nucleic acids, carbohydrates, and other biological molecules.
Prerequisite: 11:115:313 or 11:115:413.
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16:115:554
(F) Gene Regulation in Neural Development (2)
Survey of recent literature regarding the regulation of gene expression in the nervous system. Emphasis on the molecular mechanisms involved in gene regulation during neuronal development.
Abate-Shen. Offered in alternate years.
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16:115:556
(F) Ethical Scientific Conduct (1)
Introduction to ethical issues of scientific investigation, including intellectual property, plagiarism, conflict of interest, human and animal subjects, and record keeping. Intended for Ph.D. candidates in the biomedical sciences.
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16:115:601
Translational Regulation: Critical Examination of the Literature (1)
How to read and critically evaluate the scientific literature.
Kozak. Prerequisite: 16:115:502.
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16:115:605,606
Advanced Studies in Biochemistry (BA,BA)
Independent library and laboratory research into special aspects of biochemistry arranged under the supervision of faculty members in any of the participating groups.
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16:115:613,614
Seminar in Biochemistry (1,1)
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16:115:615
Quantitative Problems in Biological Sciences (2)
Provides hands-on experience in solving quantitative problems in a
workshop format typically encountered in current biological sciences
research. Practical applications to laboratory experiments will be
emphasized.
Niederman.
Corequisite: Biochemistry and molecular biology 501.
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16:115:616
Special Topics in Biochemistry (BA)
Faculty members occasionally offer a special course on a new or developing topic in biochemistry.
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16:115:701,702
Research in Biochemistry (BA,BA)
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