01:160:110 Frontiers of Chemistry (1.5) For the nonscientist, topics currently at the forefront of chemical research and their social implications. Presented by experts in layperson's terms. Recombinant DNA, chemistry of planets, chemical approaches to the harnessing of solar energy, chemical basis of disease, and drug action.

01:160:111 Chemistry of Drugs (1.5) For nonscientists, a nontechnical chemical approach to the drug phenomenon in our world. Topics include oral contraceptives, psychedelics, stimulants, and depressants.

01:160:127 Impact of Chemistry (3) Relation of chemistry to human life, culture, and everyday decisions. Case studies used to illustrate chemical principles and examine issues of current concern, such as global warming, drug testing, ozone depletion, and heavy-metal poisoning. Intended primarily for students majoring in social sciences or humanities.

01:160:128 Chemistry of Life (3) Topics chosen from fields of organic chemistry and biochemistry including proteins, DNA, RNA, and chemical origins of life. Emphasis given to the nature of chemical and biochemical discoveries and the social responsibility of scientists. Does not make a sequence with 01:160:161.

01:160:133 Preparation for General Chemistry (2) Beginning after five weeks of the semester for students who start General Chemistry and encounter serious difficulties. Fall semester only. Prerequisites: 01:640:026 or equivalent, and permission of instructor.

01:160:134 Introduction to Chemistry (3) For students who are advised that they are not ready to undertake General Chemistry. Students who have taken higher-level chemistry courses for science majors are not eligible. Fall semester only. Corequisite: 01:640:111 or 115, or appropriate performance on the placement test in mathematics.

01:160:140 The Greenhouse Effect (3) The physical and chemical bases of the "greenhouse effect" and its global impact: biological, climatic, economic, and political. Reducing the emission of "greenhouse" gases; nuclear energy and other alternative energy sources. Lec. 2 hrs., lab. 1.5 hrs. For nonscience majors; not for major credit in science or engineering. Credit not given for both this course and 01:450:140, 01:556:140, or 01:750:140.

01:160:159-160 General Chemistry for Engineers (3,3) Introduction to chemical principles and their application. Includes stoichiometry, states of matter, atomic and molecular structure, solutions, thermodynamics, equilibrium, oxidation-reduction, kinetics, nonmetals, metals and coordination compounds, and nuclear chemistry. Lec. 2 hrs., rec. 1 hr. Prerequisite or corequisite for 159: 01:640:112 or 115 or equivalent. Prerequisite for 160: 01:640:112 or 115 or equivalent. Pre- or corequisite for 160: 01:160:171. Credit not given for both these courses and 01:160:161-162 or 163-164.

01:160:161-162 General Chemistry (4,4) Introduction to chemical principles and their application. Topics include stoichiometry, states of matter, atomic and molecular structure, solutions, thermodynamics, equilibrium, oxidation-reduction, kinetics, nonmetals, metals and coordination compounds,�and nuclear chemistry. Lec. 3 hrs., rec. 1 hr. Prerequisite for 161: 01:640:111 or 115, or appropriate performance on the placement test for mathematics. Pre- or corequisite for 162: 01:160:171. Prerequisite for 162: 01:640:111 or 115 or equivalent. For science majors. Credit not given for both these courses and 01:160:159-160 or 163-164.

01:160:163-164 Honors General Chemistry (4,4) Covers topics of 01:160:161-162 in more depth. Material related to current research topics and other fields of scientific interest. Prerequisite: One year of high school chemistry. Corequisite for 163: 01:640:151 or permission of instructor. Pre- or corequisites for 164: 01:640:152 and 01:160:171, or permission of instructor. For students with a strong interest in chemistry and/or those considering majoring in a science or engineering discipline requiring a strong background in chemistry. Credit not given for both these courses and 01:160:159-160 or 161-162.

01:160:171 Introduction to Experimentation (1) Laboratory illustrating basic chemical methods. Lab fee required. Lab. 3 hrs. Pre- or corequisite: 01:160:159, 161, or 163. Prerequisite: 01:640:111 or 115 or equivalent.

01:160:192 Topics in Chemistry (1.5) Seminar on current applications of chemistry to real-world problems and issues. Practice in use of computational tools and the internet in chemical applications. Pre- or corequisites: 01:160:161 or 163 or advanced placement, and permission of department. Enrollment limited to 20 students. Intended primarily for first-year students with a strong interest in chemistry.

01:160:209 Elementary Organic Chemistry (3) Carbon compounds, including biologically and nutritionally interesting compounds, and textile polymers. Prerequisites: 01:160:127 and 128, 162, or 164. Not for major credit. Credit not given for both this course and 01:160:307-308.

01:160:211 Elementary Organic Chemistry Laboratory (1) Synthesis and analysis of organic compounds. Lab fee required. Lab. 3 hrs. Prerequisite: 01:160:171. Pre- or corequisite: 01:160:209.

01:160:251 Analytical Chemistry (3) Quantitative applications of gravimetric, volumetric, and instrumental methods of analysis to samples of environmental significance. Offered fall and spring semesters. Lab fee required. Lec. 1.5 hr., lab. 4.5 hrs. Prerequisites: 01:160:171 and 160, 162, or 164.

01:160:305-306 Organic Chemistry (3,3) Basic theory. Survey of structure, properties, and reactivity of main classes of compounds, including a number of biological interest. Lec. 3 hrs. Prerequisite: 01:160:160, 162, or 164. Note: 01:160:305 does not substitute for 01:160:209. Credit not given for both these courses and 01:160:307-308 or 315-316.

01:160:307-308 Organic Chemistry (4,4) Basic theory. Survey of structure, properties, and reactivity of main classes of compounds, including a number of biological interest. Lec. 3 hrs., rec. 1 hr. Prerequisite: 01:160:160, 162, or 164. 01:160:307 does not substitute for 01:160:209. Credit not given for both 01:160:307-308 and 305-306 or 315-316.

01:160:309-310 Organic Chemistry Laboratory (2.5,2.5) Develops proficiency in preparation and manipulation. Hands-on use of modern spectroscopic and chromatographic instrumentation (FT-NMR, FT-IR, GC, GCMS). Lab fee required.
Lec. 1 hr., lab. 4.5 hrs. Prerequisite for 309: 01:160:171. Pre- or corequisite for 309: 01:160:308 or 316. Prerequisites for 310: 01:160:309, and 308 or 316. Open only to students majoring in chemistry, biochemistry, chemical engineering, and molecular biology and biochemistry, or by permission of instructor.

01:160:311 Organic Chemistry Laboratory (2) Develops facility in both preparation and manipulation and applies chromatographic and spectroscopic techniques to solutions of problems. Lab fee required.
Lec. 1 hr., lab. 4.5 hrs. Prerequisites: 01:160:171 and 307.

01:160:313-314 Organic Chemistry Laboratory (1,1) Develops proficiency in preparation and manipulation. Chromatographic and spectroscopic techniques applied to solutions of problems. Qualitative organic analysis.
Lab. 3 hrs. Prerequisites for 313: 01:160:171; 01:160:160, 162, or 164. Prerequisites for 314: 01:160:305 or 307 or 315, and 313. Pre- or corequisite for 313: 01:160:305 or 307 or 315. Pre- or corequisite for 314: 001:160:306, 308, or 316. 01:160:313-314 is equivalent to 01:160:311. Offered in summer only.

01:160:315-316 Honors Organic Chemistry (4,4) Survey of structure, properties, and reactivity of main classes of organic compounds with a focus on qualitative molecular orbital theory, reaction mechanisms, and synthesis.
Lec. 3 hrs., rec. 1 hr. Prerequisite: 01:160:160, 162, or 164. Corequisite for 316: 01:160:309. 01:160:209 does not substitute for 01:160:315. Credit not given for both 01:160:315-316 and 305-306 or 307-308. Recommended for students planning to pursue graduate work in chemistry, biochemistry, molecular biology, or medicine.

01:160:323-324 Physical Chemistry (3,3) Fundamental principles of physical chemistry. Quantum theory, spectroscopy, statistical mechanics, thermodynamics, and kinetics. Prerequisites: 01:160:160, 162, or 164; 01:640:251; 01:750:203-204, or 227 and 228. Credit not given for both these courses and 01:160:327-328 or 341-342.

01:160:327-328 Physical Chemistry (4,4) Fundamental principles of physical chemistry. Quantum theory, spectroscopy, statistical mechanics, thermodynamics, and kinetics. Lec. 3 hrs., rec. 1 hr. Prerequisites: 01:160:160, 162, or 164; 01:640:251; 01:750:203-204, or 227 and 228. Credit not given for both these courses and 01:160:323-324 or 341-342. Equivalent to 01:160:323-324 but includes a recitation.

01:160:329 Experimental Physical Chemistry (2.5) Experiments in physical chemistry illustrating principles and techniques. Use of computers to process experimental data. Lec. 1 hr., lab. 4.5 hrs. Prerequisites: 01:160:251 and 323, 327, or 341.

01:160:341-342 Physical Chemistry: Biochemical Systems (3,3) Fundamental principles of physical chemistry: thermodynamics, ideal and nonideal solutions, chemical dynamics, catalysis, electrochemistry, and phase equilibria. Biologically relevant examples and applications stressed. Prerequisites: 01:160:160, 162, or 164; 01:640:251; 01:750:203-204, or 227 and 228. Credit not given for both these courses and 01:160:323-324 or 327-328.

01:160:344 Introduction to Molecular Biophysics Research (3) Basic principles and methods of research, followed by a research project involving preparation of biopolymer analogs, X-ray crystallography, spectroscopy, calorimetry, computer simulation, and other relevant physical techniques. Description of research opportunities at the university available to undergraduates. Prerequisites: 01:160:309 and 323, 327, or 341, and permission of instructor.

01:160:348 Instrumental Analysis (3) Theory and practice of instrumental analysis, including electrochemistry, separations, and spectroscopy. Lec. 80 mins., lab. 5 hrs. Prerequisite: 01:160:251. Intended for chemistry majors.

01:160:361 Chemical Bonding (1.5) Theories of ionic and covalent bonding. Elementary molecular orbital theory applied to simple molecules.
Prerequisites: 01:160:305, 307, or 315 and 01:640:152 or equivalent.

01:160:371 Inorganic Chemistry (3) Introduction to the bonding, electronic structure, and chemical properties of transition metal and main group inorganic compounds.
Prerequisites: 01:160:308 and 361, or permission of instructor.

01:160:391-392 Independent Study in Chemistry (1-3,1-3) Research on an original problem under the direction of a member of the department. Written report and one oral or poster presentation required. Prerequisite: Permission of department. Not open to seniors.

01:160:409 Organic Chemistry of High Polymers (3) Introduction to the synthesis and reactions of macromolecules, free-radical polymerization, stereospecific polymerization, and stepwise polymerization.
Prerequisites: 01:160:308 and 324, 328, or 342.

01:160:410 Introduction to Molecular Modeling (3) Introduction to computer-assisted molecular modeling techniques for the study of chemical problems. Lectures on theoretical principles. Instruction in use of modern modeling programs. Computer projects involving solution of chemical problems. Prerequisites: 01:160:307-308 and 323-324 or equivalent.

01:160:411-412 Advanced Organic Chemistry (3,3) Advanced survey of organic chemistry; structure and stereochemistry of organic molecules, chemistry of reactive intermediates,�structure-reactivity relationships, molecular rearrangements, molecular orbital theory, and orbital symmetry correlations. Prerequisites: 01:160:308 and 324, 328, or 342.

01:160:415 Theory and Interpretation of Organic Spectra (3) Theory and interpretation of nuclear magnetic resonance, infrared, ultraviolet, and mass spectra. Prerequisites: 01:160:308 and 324, 328, or 342.

01:160:418 Bioorganic Mechanisms (3) Catalysis of organic reactions that are model systems for enzymatic processes. Emphasis on mechanisms of enzyme catalyzed reactions. Prerequisites: 01:160:308 and 324, 328, or 342.

01:160:421 Atomic and Molecular Structure (3) Introduction to quantum mechanics and statistical mechanics. Elementary solutions of the Schr�dinger wave equation; valence bond and molecular orbital theory; Boltzmann distribution; partition functions. Prerequisites: 01:160:324, 328, or 342; 01:640:250 and 251 or equivalent.

01:160:422 Statistical Mechanics (3) Basic concepts and methods of equilibrium statistical mechanics. Applications to systems and phenomena of chemical interest, including ideal and real gases, chemical equilibria, phase transitions, classical liquids, and polymer solutions. Use of Monte-Carlo and molecular dynamics simulations to solve problems of current interest. Prerequisites: 01:160:324, 328, or 342; 01:640:250 and 251 or equivalent.

01:160:425 Thermodynamics I (3) Principles of classical and statistical thermodynamics, treated in an integral manner; interrelations of molecular properties with the energy and entropy of macroscopic systems. Applications include phase changes and chemical reactions. Prerequisites: 01:160:327-328 or equivalent.

01:160:426 Thermodynamics II (3) Application of thermodynamics to solutions of nonelectrolytes and electrolytes. Prerequisite: 01:160:425.

01:160:433 Chemical Application of Group Theory (3) Aspects and consequences of molecular symmetry; point groups and character tables; group theory and quantum mechanics; symmetry aspects of the electronic structure in organic and inorganic molecules; selection rules for electronic and vibrational spectroscopy; ligand field theory. Prerequisite: 01:160:421 or permission of instructor.

01:160:434 Kinetics (3) Chemical reaction rates in homogeneous systems and at interfaces. Experimental and mathematical methods of elucidating reaction mechanisms. Photochemical and ultrafast reactions. Prerequisite: 01:160:324, 328, or 342 or equivalent.

01:160:437 Physical Chemistry of Biological Systems (3) Introduction to the physical chemistry of proteins, nucleic acids, and their complexes. Forces that determine biopolymer structure. Principles of protein and nucleic acid structure. Transitions and interactions of biopolymers. Prerequisite: 01:160:324, 328, or 342 or equivalent. Recommended: 11:115:403,404 or 01:694:407,408 previously or concurrently.

01:160:438 Introduction to Computational Chemistry (3) Solution of chemical problems using computer and graphics equipment. Applications to molecular structure and reactivity, conformational analysis, molecular interactions, and dynamics. Prerequisite: 01:160:324, 328, or 342 or permission of instructor.

01:160:439 Physical Chemistry of the Environment (3) Application of physical chemical principles to environmental problems. Prerequisite: 01:160:324 or 328 or equivalent.

01:160:446 Chemical Separations (3) The principles of chemical separations by various chromatographic techniques. Prerequisite: 01:160:324 or 328 or equivalent.

01:160:451 Analytical Spectroscopy (3) Theory of spectroscopy and spectrophotometry, including the analytical applications of spectrochemical methods. Prerequisites: 01:160:324 or 328, and a course in analytical chemistry.

01:160:459 Electroanalytic Chemistry (3) Theory and instrumental techniques that encompass static and dynamic electroanalytical measurements. Topics include potentiometry, voltammetry, coulometry, basic instrumentation/operational amplifiers, and new applications. Focus on analytical applications and utilizing the correct technique for solving specific analysis problems.
Prerequisite: Permission of department. Credit not given for both this course and 16:160:549.

01:160:461 Concepts in Nanochemistry (3) Nanochemistry: synthesis and characterization of organic and inorganic materials with nanoscale dimensions; electronic and magnetic properties; applications in medicine, energy, and toxicology. Prerequisite: 01:160:361 or 327.

01:160:471 Advanced Inorganic Chemistry (3) Advanced treatment of bonding, electronic-spectral, magnetic, and chemical properties of transition metal complexes. Prerequisites: 01:160:371 and 421, or equivalent.

01:160:475 Organometallic Chemistry (3) A detailed survey of the mechanisms of organometallic reactions. Prerequisites: 01:160:308, 324 or 328, 371.

01:160:476 Bioinorganic Chemistry (3) Spectroscopic, chemical, and other properties of metal-containing biological systems such as hemoglobin, vitamin B12, carboxypeptidase, etc. Prerequisite: 01:160:371 or equivalent.

01:160:480 Structural Biology, Structural Biophysics, and Chemical Biology of Transcription (3) Transcription and transcriptional regulation. Structures and mechanisms of RNA polymerase, initiation factors, elongation factors, activators, repressors, promoters, and terminators. Protein-DNA interactions, protein-protein interactions, and use of energy to drive conformational changes and translocation. Emphasis on RNA polymerase as a molecular machine. Prerequisites: 01:160:305-306, 307-308, 315-316, or equivalent; 01:160:323-324, 327-328, 342, 11:115:409, 16:160:537, or equivalent (may be taken concurrently); 01:694:407-408, 11:115:403-404, 16:115:501-502, 511-512, and permission of the instructor.

01:160:487,488 Special Topics in Chemistry (3,3) Study of selected areas in chemistry. Prerequisite: Permission of instructor.

01:160:491-492 Seminar in Chemistry (1,1) Development of communication skills needed by professionals in chemistry and related fields. Oral reports, discussions of topics of current interest, journal club, and poster sessions. Introduction to the chemical research literature. Open only to seniors.

01:160:493-494 Internship in Chemistry (1-8) Work in chemistry with a designated community partner; an appropriately designed academic project resulting in a written and/or oral report. Corequisites: 01:160:491-492. Open only to seniors. Graded Pass/No Credit.

01:160:495-496 Senior Research Project: Chemistry (1-6,1-6) Research on an original problem under the direction of a member of the department. Written report and one oral or poster presentation required. Prerequisite: Permission of department. Open only to seniors.

01:160:497-498 Honors Research in Chemistry (3-6,3-6) Research on an original problem under the direction of a member of the department. Written report and one oral presentation required. Prerequisite: Permission of department. Open only to senior honors students.

01:160:499 Introduction to Teaching Chemistry Lab (3) Provides outstanding science majors with the opportunity to teach at the undergraduate level. Under the direction of a senior faculty member, participants supervise a section of a first-year chemistry laboratory. Prerequisites: 01:160:159-160 or 161-162 or 165-166; 01:160:307-308 or 315-316; and labs: 01:160:171, 309 or 310 or 311. For outstanding science majors only, minimum GPA 3.5. By invitation only.