01:694:214
Introduction to Molecular Biology and Biochemistry (3)
Basic principles and methods of research, followed by a research project: analyses of molecular clones from eukaryotic cDNA libraries. Description of research opportunities
available to undergraduates at the university.
Prerequisites: For first-year students only who have placed out of General Biology (01:119:101-102) with AP credits, and 01:160:161 or 01:160:163. Corequisite: 01:160:162 or 164.
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01:694:215
Honors Introduction to Molecular Biology and Biochemistry Research (3)
Basic principles and methods of research, followed by a research project: isolation and analyses of transcriptional regulatory mutants in yeast. Description of research opportunities that are available to undergraduates at the university.
Prerequisite: Limited only to first-year SAS honors students who have placed out of General Biology (01:119:101-102) with AP credits. Corequisite: 01:160:161 or 163.
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01:694:230
Analytical Methods in Biology (3)
Mathematical methods and tools to analyze and interpret
biological and biomedical data, including probability theory; Bayes Theorem;
the binomial, Poisson, and normal distributions; limit theorems; error analysis;
tests of statistical significance; parameter estimation; curve fitting;
sampling techniques; random number generation; and Monte Carlo methods. Analysis of sequencing and microarray data, such as sequence alignment,
phylogeny inference, population structure, selection, and human migration.
Prerequisites: 01:119:101-102 and 01:640:135 or 151.
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01:694:281,282
Sophomore Laboratory Research (1-6,1-6)
Research project in the laboratory of a faculty member. Written report of research carried out during each semester required. Credits in this course cannot be used toward the required research credits for laboratory option.
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01:694:301
Introductory Biochemistry and Molecular Biology (3)
Chemistry and metabolism of proteins, carbohydrates, lipids, nucleic acids, and other biologically important compounds.
Prerequisite: 01:160:209 or 307. Not for students majoring in molecular biology and biochemistry. Credit not given for both this course and 01:694:407, 11:115:301, or 11:115:403.
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01:694:313
Introductory Biochemistry Laboratory (1)
Techniques used in research, clinical, and food laboratories, including
tests of biological materials, methods of separation, and determination
of enzyme activities.
Lab. 3 hrs. Pre- or corequisite: 01:694:301. Not for students majoring in molecular biology and biochemistry.
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01:694:315
Introduction to Molecular Biology and Biochemistry Research (3)
Basic principles and methods of research, followed by a research
project: analyses of molecular clones from eukaryotic cDNA libraries.
Description of research opportunities at the university available to
undergraduates.
Pre- or corequisites: 01:119:101-102, and 01:160:161-162, 171 or 01:160:163-164, 171. Credit not given for both this course and 01:447:315.
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01:694:381,382
Undergraduate Laboratory Research (3-6,3-6)
Research project in the laboratory of a faculty member. Written report of research carried out during each semester required.
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01:694:383
Seminar in Molecular Biology and Biochemistry: Careers in Science (1)
Discussion of career options in the life sciences, finding a research laboratory, performing literature searches, reading a scientific
paper, and creating posters and abstracts. This course should be taken in the
beginning of the third year.
Open to MBB majors only.
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01:694:407
Biochemistry (3)
Protein structure and function, structure of lipids, membranes and carbohydrates, catalysis of biochemical reactions, intermediary metabolism, oxidative phosphorylation, membrane transport, lipid metabolism, signal transduction, photosynthesis, protein secretion, targeting and turnover, nitrogen, amino acid, and nucleotide metabolism.
Pre- or corequisites: 01:160:307-308 or 315-316. Credit not given for both 01:694:407 and 01:694:301, 11:115:301, or 11:115:403.
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01:694:408
Molecular Biology and Biochemistry (3)
Disciplines of biochemistry and molecular biology as
interlocking and mutually complementary fields of study. Lectures on structure
of DNA, RNA, recombinant DNA approaches, DNA replication, repair and
recombination, mobile genetic elements, transcription, gene regulation, RNA
splicing, translation, and viral gene expression.
Pre- or corequisites: 01:694:407 (preferred), or 01:694:301, or 11:115:403. Credit not given for both 01:694:408 and 01:146:478 or 11:126:481.
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01:694:411
Molecular Pathways and Signal Transduction (3)
Lectures and discussion of current research areas of advanced molecular
and structural biology: transcription, posttranscriptional regulation,
cell cycle, neurobiology, protein folding, macromolecular recognition,
and molecular virology.
Prerequisites: 01:694:407 and 408, or 01:447:384-385 or 11:115:403-404 or 11:126:481.
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01:694:412
Proteomics and Functional Genomics (3)
Survey of modern techniques of protein biochemistry, bioinformatics,
proteomics, and functional genomics, including basic concepts of
protein structure and function, protein folding, protein
characterization and purification, enzyme kinetics, NMR and X-ray
crystallography, mass spectrometry, yeast two hybrid, and various techniques and
approaches to functional and structural genomics.
Prerequisites: 01:694:407 and 01:447:380 (or 01:447:384), or permission of instructor. Corequisite: 01:694:408 or permission of instructor.
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01:694:413
Chromatin and Epigenomics (3)
Introduction to chromatin dynamics, particularly the structural and biochemical modifications of chromatin that underlie epigenetic states and their effects on gene expression and development.
Prerequisite: 01:694:408 or 01:146:478 or 01:447:385.
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01:694:414
Harnessing Solar Energy (3)
Strategies used by nature to absorb and convert solar energy
into other forms for storage or work (force generation). Quantitative accounting
of solar energy utilization and losses in biology and analogous manmade solar
devices and biological energy conversion (energy metabolism). Natural
photosynthesis and how efficiently it can harness solar energy to produce
biofuels. Emerging knowledge will be
presented on the development of the synthetic "artificial leaf. "
Prerequisites: 01:119:101-102 and 01:160:307 or 01:160:315, and 01:750:203 or 01:750:201 or 01:750:194, and 01:640:151 or 01:640:135, and 01:160:308 or 01:160:316, and 01:640:152 or 01:640:138, and 01:750:204 or 01:750:202 or 01:750:195.
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01:694:420,421
Special Topics in Molecular Biology and Biochemistry (3,3)
Directed reading and discussion of
selected topics of special interest in molecular biology and biochemistry.
Topics will vary according to semester and/or instructor.
Prerequisite: 01:694:408.
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01:694:481,482
Advanced Undergraduate Laboratory Research (3-6,3-6)
Research
project in the laboratory of a faculty member. A written report of research
carried out during each semester is required. Oral presentations of student
research are required in 01:694:484.
Pre- or corequisites: 01:694:214, 215 or 315, 407, 408, and 383. Students must complete a Special Permission Form and have it signed by their research and MBB faculty mentors before they can register for the course.
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01:694:484
Seminar in Molecular Biology and Biochemistry: Research Presentations (1)
Oral presentation of student's own research results and the research
interests of the laboratory with which the student is associated.
Presentation at a required poster session.
Students should take this course in the spring semester of their senior year. MBB majors only. Pre- or corequisites: 01:694:214, 215 or 315, 381,382, 407, and 408; or 01:694:481,482, 489,490, or 495,496.
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01:694:489,490
Literature Research in Molecular Biology and Biochemistry (1-3,1-3)
Literature research projects on a selected subject under the direction
of a faculty member. A
written report of research carried out during each semester is required. Oral
presentations of student research are required in 01:694:484.
Prerequisites: 01:694:214, 215 or 315, 407, 408, and 383.
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01:694:492
Gene Regulation in Cancer and Development (3)
Molecular biology is an experimental science, and a major goal of this course is to explain not just what molecular biologists know, but how they know it. Thus, while covering selected topics in gene regulation, development, and cancer, we will emphasize the methods, experimental design, history, and deductive reasoning that has led to the current state of understanding of these topics.
Pre- or corequisites: 01:694:407, 408, or 01:447:384-385 or 11:115:403-404 or 11:126:481.
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01:694:495,496
Honors Laboratory Research (6,6)
Honors research project in the laboratory of a faculty member. Students are required to attend a weekly seminar in the fall semester on how to write a thesis. Oral
presentations of student research presented in 01:694:484. Honors
thesis and oral presentation required.
Pre- or corequisites: 01:694:214, 215 or 315, 407, 408, and 383, 484.
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