Biomedical Engineering 125

14:125:201 Introduction to Biomedical Engineering (3) Overview of applications of engineering in medicine and health care. Introduction to biological and biomedical problems using fundamental concepts and tools from electrical, mechanical, and chemical engineering. Prerequisites: 01:640:152, 01:750:124.

14:125:208 Introduction to Biomechanics (3) Relationship between applied and resultant forces and stresses acting on the musculoskeletal system. Basic concepts of vectors, internal and external forces, functional anatomy, trusses and equilibria of spatial force systems, moments, and work and energy concepts. Stress and strain tensors, principal forces, viscoelasticity, and failure analysis from classical mechanics.   Prerequisites: 01:750:124, 228; 14:440:221. Corequisite: 01:640:244.

14:125:301 Introduction to Packaging Engineering (3) Prerequisites: 01:640:152, 01:750:124.

14:125:303 Biomedical Transport Phenomena (3) Biomedical mass transport processes involving diffusion, diffusion-convection, and diffusion-reaction schemes; introduction to biofluid dynamics; transport processes in the cardiovascular system, hemorheology, extracorporeal mass transport devices, and tissue engineering. Prerequisites: 14:125:201, 309, and 310; 01:640:244.

14:125:305 Numerical Modeling in Biomedical Systems (3) Introduction to modeling and simulation techniques in the analysis of biomedical systems. Application of numerical methods for the solution of complex biomedical process problems. Development and use of PC software for the analysis and solution of engineering problems. Prerequisites: 14:125:201 and 309, 01:640:244, 14:440:127.

14:125:306 Kinetics and Thermodynamics of Biological Systems (3) Fundamentals of thermodynamics and kinetic analysis as applied to biomedical systems and technologies. Essential principles in thermodynamics introduced, including First Law, Second Law, and interrelationships among thermodynamic variables. Fundamental tools in kinetic analysis are also covered, including interpretation of rate data, enzyme kinetics, and pharmacokinetics. Application to biological systems and biomedical technologies are provided. Prerequisites: 01:119:102, 01:160:160, 01:640:244, 14:125:303 and 305.

14:125:309 Biomedical Devices and Systems (3) Time and frequency domain analysis of electrical networks; hydrodynamic, mechanical, and thermal analogs; basic medical electronics, and energy conversion systems. Design of biological sensors. Prerequisites: 01:640:251, 01:750:227 and 229, 14:125:201. Corequisite: 14:125:310.

14:125:310 Biomedical Devices and Systems Laboratory (1) Experiments and demonstrations dealing with basic medical electronics and signal analysis. Provides an overview of current biomedical technology and its uses. Prerequisites: 14:125:201 and 01:640:251, 01:750:227 and 229. Corequisite: 14:125:309.

14:125:315 BME Measurement and Analysis Laboratory (2) Experiments and demonstrations dealing with the measurement and analysis of various physiological quantities of cardiovascular and respiratory systems, and the measurement of cellular viability, metabolism, morphogenesis, and protein and nucleic acid composition. Prerequisites: 14:125:309, 310.

14:125:371 Packaging Evaluation Methods (3) Methods for evaluating and characterizing packaging materials and manufactured packages discussed, with emphasis on package development and established test protocols.

14:125:373 Packaging Evaluation Laboratory (1) Experiments performed to evaluate the performance of manufactured packages and materials used for packaging. Mechanical and chemical properties of packaging materials determined.   Lab. 3 hrs.  Prerequisite: 14:125:302. Corequisite: 14:125:371.

14:125:401,402 Biomedical Engineering Senior Design I,II (3,3) Students gain design experience in the biomedical engineering field by completing a design project under the supervision of a faculty member. Project typically involves experimental or computational study of a design-oriented problem in biomedical engineering. Prerequisites: 14:125:208, 303, 305, 306, 315.

14:125:403 Cardiovascular Engineering (3) Introduction to modeling and measurement methods for the cardiovascular system, analysis of blood flow dynamics, the function of the heart, and noninvasive approaches. Applications to cardiovascular instrumentation, basic cardiovascular system research, assist devices, and disease processes. Prerequisites: 14:125:303, 306, 308, 315.

14:125:404 Introduction to Biomaterials (3) Introduction to material properties, testing, biomaterial requirements, and device design. The main objective is to convey basic knowledge of this large volume of information and to provide an elementary understanding of the terminology used in academic and commercial settings as preparation for future study or work. Prerequisites: 14:125:303, 305, 308.

14:125:405 Introduction to Neural Processes (3) Introduction to the function of the nervous system and its building blocks, the neurons. Basic functional characteristics of neurons as individual elements and as parts of neuronal assemblies; generator and action potentials; conduction in nerve fibers and across synaptic junctions; analysis of sensory and neuromuscular systems; EEG and EKG waveforms. Introduction to artificial and electronic equivalents of neurons or neural networks. Prerequisites: 14:125:303, 305, 306, 308, 315.

14:125:407 Fundamentals of Computer Tomography (3) Principles of 3D reconstruction from projections in medicine. Mathematics of reconstruction from projections; application to X-ray, Magnetic Resonance Emission Tomography, and ultrasound. Prerequisites: 14:125:303, 305.

14:125:409 Introduction to Prosthetic and Orthotic Devices (3) The course introduces the application of mechanical engineering principles to the design of artificial limbs and braces. Teaching includes basic anatomy and physiology of limb defects, biomechanics, motion analysis, and current device designs. Design and visualization tools will include MatLab, and other application software. Prerequisites: 14:125:208, 303, and 315. Crosslisted with 16:125:540.

14:125:410 Sensory Processes, Mechanisms, and Computational Models (3) General principles of information processing in the human sensory organs, as well as in the early, low-level neural mechanisms and pathways that transmit the signals to the cortex. Emphasis placed on the sensory organs and pathways of vision and audition. Mechanisms covered from a neurophysiological, a computational modeling, and a psychophysical point of view. Prerequisites: 14:125:305 and 315.

14:125:411 Bioelectric Systems (3) Introduction to the understanding of bioelectric phenomena that occur in physiological systems. This includes the origin of biopotentials, the use of biopotential electrodes in their measurements and subsequent amplification, signal processing and analysis of their physiological relevance. Applications of physical principles and basic electric engineering techniques are emphasized. Prerequisites: 14:125:210,211 or 309,310.

14:125:414 Vision Research and Instrumentation (3) Comprehensive overview of the visual system, beginning with fundamental properties and progressing to the level of current research in vision. Evaluation of experimental and modeling results in vision research, in-depth review of journal articles, and hands-on demonstrations of state-of-the-art visual system instrumentation. Prerequisites: 14:125:303, 305, 306, 315.

14:125:416 Pattern Recognition in Machines and Biological Systems (3) Principles of pattern recognition in the visual system within the context of information processing in living organisms and computers. Topics include pattern formation, interpretation, and classification; computer vision compared to biological vision. Prerequisite: 14:125:315.

14:125:417 Introduction to Musculoskeletal Mechanics (3) Introduction to motion-actuating, force generating, and load-supporting mechanisms in musculoskeletal system, as explained from basic engineering principles. Elucidation of function-structure relationships from both ultrastructural and mechanical analyses. Experimental and analytical approaches to solve realistic orthopaedic and recreational problems. Prerequisite: 14:125:208.

14:125:418 Applied Electronics for Biomedical Engineers (4) This course will provide both the theory and application of analog circuit design, microprocessor interfacing, and digital signal processing (DSP). Emphasis will be placed on the special requirements of medical instrumentation and biological measurements including the use of selected biomedical transducers. An integrated laboratory will use both simulation and breadboard techniques to provide "hands-on" experience with the design, construction, and evaluation of analog circuits. Prerequisites: 14:125:201, 301 or 309, 310 or 14:332:373, 375 or 14:332:221-222, 223-224.

14:125:424 Biomedical Instrumentation Laboratory (3) Practical hands-on designs of biomedical instrumentation including biopotential and physiological signal processing amplifiers, electrodes, biosensor and transducers, electro-optical, acoustic, and ultrasonic devices. Prerequisite: 14:125:315.

14:125:431 Introduction to Optical Imaging (3) Introductory overview of optical phenomena and the optical properties of biological tissue. The course is specifically focused on optical imaging applications in biology and medicine. Topics will include reflection, refraction, interference, diffraction, polarization, light scattering, fluorescence and Raman techniques, and their application in biomedical imaging and microscopy. Prerequisite: 14:125:303, 210 or 310, or permission of instructor.

14:125:432 Cytomechanics (3) Structural and mechanical components of cells, with emphasis on the regulatory roles of physical forces in cell function. Emphasis on processes that drive tissue growth, signaling and metabolism, gene expression, and biomechanical properties of cells and their components. Prerequisites: 14:125:303, 208, 308. Crosslisted: 16:125:532.

14:125:433 Fundamentals and Tools of Tissue Engineering (3) Fundamentals of polymer scaffolds and their use in artificial tissues. Regulation of cell responses in the rational design and development of engineered replacement tissue. Understanding the biological, chemical, and mechanical components of intra- and intercellular communication. Preliminary discussions on real-life clinical experiences. Prerequisite: 14:125:303.

14:125:434 Tissue Engineering II: Biomedical and Biotechnological Applications (3) Applications of tissue engineering and builds upon the prior course fundamentals and tools. Emphasis is placed on applying the fundamental principles and concepts to problems in clinical medicine and large scale industrial manufacturing. Topics include skin replacement, cartilage tissue repair, bone tissue engineering, nerve regeneration, corneal and retinal transplants, ligaments and tendons, blood substitutes, artificial pancreas, artificial liver, tissue integration with prosthetics, vascular grafts, cell encapsulation, and angiogenesis. Prerequisite: 14:125:433 or permission of instructor.

14:125:436 Introduction to Molecular and Cellular Bioengineering (3) Overview of existing and emerging technologies that exploit our knowledge of molecular and cell biology for applications related to medicine. Topics include genome sequencing; gene expression measurements and applications; protein structure, activity, and detection; biomolecular network analysis and cellular integration of biological signals; cellular processes; cells at interfaces; design and integration of biological components for devices and advanced therapeutics. Prerequisites: 14:125:303, 306, 315.

14:125:450 Science and Engineering in Medicine (3) Scientific principles on which a variety of medical instruments are based and evaluation of the impact of these technologies on the practice of medicine. Review of the technologies from pathology, neurosurgery, ophthalmology, radiology, cardiothoracic surgery, orthopedic surgery, and plastic surgery. Prerequisite: 14:125:310 or permission of instructor.

14:125:468 Packaging Machinery (3) Study of packaging machinery with some review of materials and considerations of the interrelationship between machinery and materials. Analysis of the development of package production lines. Principles of machine design and selection emphasizing the synthesis of knowledge. Prerequisite: 14:125:301. Corequisite: 14:125:470.

14:125:470 Packaging Machinery Laboratory (1) Laboratory experimentation to accompany 14:125:468. Designed to augment the principles and practices presented in the lectures. Complete packaging line used by students for experiments. 
Lab. 3 hrs. Prerequisite: 14:125:301. Corequisite: 14:125:468.

14:125:471 Distribution Packaging (3) Design, development, and evaluation of distribution packaging. Physical distribution management as a systems approach to the flow, storage, and control of the product. Equipment used in distribution packaging. Economics of package design. Prerequisite: 14:125:301. Corequisite: 14:125:473.

14:125:473 Distribution Packaging Laboratory (1) Experiments in design of distribution packages, cushioning of products, and testing in a simulated distribution environment. Builds on principles studied in 14:125:471.
Lab. 3 hrs. Prerequisite: 14:125:301. Corequisite: 14:125:471.

14:125:489 or 490 Advanced Research in Biomedical Engineering (3) **Junior Year Advanced research immersion activity and the supporting educational tools for members of the BME Honors Academy who participate within a formalized two-year research experience. Students work independently with faculty members on a research project of relevance to biomedical engineering. In addition, students meet monthly for roundtable discussions of a wide range of scientific ethical and professional issues. Prerequisite: Biomedical Engineering Honors Academy students only.

14:125:491,492 Special Problems in Biomedical Engineering (3,3) Independent study under the guidance of a faculty member in specific areas of interest in biomedical engineering. Prerequisite: By permission.

14:125:493,494 Advanced Research in Biomedical Engineering (3,3) **Seniors Advanced research immersion activity and the supporting educational tools for members of the BME Honors Academy who participate within a formalized two-year research experience. Students work independently with faculty members on a research project of relevance to biomedical engineering. In addition, students meet monthly for roundtable discussions of a wide range of scientific ethical and professional issues. Prerequisite:  Biomedical Engineering Honors Academy students only.

14:125:496,497 Co-op Program in Biomedical Engineering (3,3) Provides the student with the opportunity to practice and apply knowledge and skills in various biomedical engineering environments. Provides a capstone experience to the undergraduate experience by integrating prior coursework into a working engineering environment. Prerequisites: Senior standing in biomedical engineering and special permission.