01:146:201,202 Independent Study in Cell Biology and Neuroscience (1-3,1-3) Independent study under the direction of a member of the faculty. Written report required.� Prerequisites: Permission of department and an instructor willing to sponsor the student, and a cumulative grade-point average of 2.8 or better. May not be used to fulfill a laboratory requirement. Open only to students majoring or planning to major in cell biology and neuroscience.

01:146:245 Fundamentals of Neurobiology (3) Introduction to the biology of the nervous system. Topics covered include nerve cell signaling, sensory and motor systems, and higher brain processes. Prerequisites: 01:119:101-102.

01:146:270 Fundamentals of Cell and Developmental Biology (3) Principles of cell biology. Structure, function, and macromolecular organization of cellular organelles. Prerequisites: 01:119:101-102.

01:146:295 Essentials of Cell Biology and Neuroscience (3) Provides a solid background in cell biology and neuroscience necessary for understanding new scientific achievements in these fields. Topics range from regulation of gene transcription to neural signaling and cognition, with a focus on remediation of neurological disorders. Prerequisites: 01:119:101-102. Not for cell biology and neuroscience majors.

01:146:307,308 Research in Cell Biology and Neuroscience (1-3,1-3)

Laboratory research on an original problem under the direction of a member of the faculty. Written report required.

Prerequisites: Permission of department and an instructor willing to sponsor the student and a cumulative grade-point average of 2.8 or better. Open only to students majoring or planning to major in cell biology and neuroscience.

01:146:322 Animal Histology (4)

Structure of the tissues and organs of the animal body.

Lec. 3 hrs., lab. 3 hrs. Prerequisite: 01:146:270 or 01:146:295. (Formerly 01:119:322).

01:146:328 Human Parasitology (3)

Discussion of the cell biology, epidemiology, pathogenesis, and clinical manifestations of human parasitic diseases.

Lec. 3 hrs. Prerequisites: 01:119:101-102.

01:146:329 Human Parasitology Laboratory (1)

Laboratory to accompany 01:146:328.

Lab. 3 hrs. Pre- or corequisite: 01:146:328.

01:146:356 Systems Physiology (3)

Comprehensive study of the principal organ systems of laboratory animals and humans.

Prerequisites: 01:119:101-102 and 01:160:161-162 or 163-164, and 171. Credit not given for both this course and 11:067:300.

01:146:357 Systems Physiology Laboratory (1) Laboratory to accompany 01:146:356.� Lab. 3 hrs. Pre- or corequisite: 01:146:356.

01:146:405 Honors Seminar (3) Development of communication and written skills needed by professionals in cell biology and neuroscience. Oral reports, written�papers, and discussion of topics of current interest in the field.� Prerequisite: Permission of department. Open only to senior honors students.

01:146:406-407 Research in Cell Biology and Neuroscience (1-4,1-4) Research under the direction of a member of the departmental faculty. Written report required. Prerequisites: Permission of department and an instructor willing to sponsor the student and a cumulative grade-point average of 2.8 or better. Open only to students majoring in cell biology and neuroscience.

01:146:408-409 Honors Research (3-6,3-6) Research project under the direction of a departmental faculty member. Written report and oral presentation required.
Prerequisites: Permission of department and an instructor willing to sponsor the student. Open only to seniors majoring in cell biology and neuroscience who meet the requirements for the departmental honors program.

01:146:445 Advanced Neurobiology I (4)

Advanced concepts in neurobiology focusing on cellular and molecular aspects of neuronal signaling, including ion channel gating, sensory transduction, and transmission across chemical and electrical synapses.

Prerequisite: 01:146:245 and 270.

01:146:446 Advanced Neurobiology Laboratory I (3) Advanced laboratory methods in neurobiology. Electrophysiological and immunochemical techniques to explore the structural and functional features of nerve cells.� Prerequisites: 01:146:445 and permission of instructor.

01:146:447 Advanced Neurobiology II (3) Focuses on the neurobiology of disease, with four modules: developmental disorders, injury to brain and spinal cord, regeneration, and neurodegenerative diseases, including Alzheimer's disease. Prerequisites: 01:146:245 and 270.

01:146:448 Advanced Neurobiology Laboratory II (3) Advanced laboratory methods in molecular neurobiology.� Study of neuronal differentiation, neurite outgrowth, and neuronal protein trafficking using molecular biological, cell biological, and biochemical techniques.
Prerequisites: 01:146:445 and permission of instructor.

01:146:464 Topics in Cell Biology and Neuroscience (3) Directed readings and discussion of selected topics in cell biology and neuroscience. Prerequisites: 01:146:245 and 270.

01:146:470 Advanced Cell Biology (3) Advanced concepts of cell biology focusing on the molecular organization of cells, including internal membranes and synthesis of macromolecules, the cell nucleus, the cell cycle, cytoskeleton, cell-cell adhesion and the extracellular matrix, and signal transduction.
Prerequisite: 01:146:270. Credit not given for both this course and 01:119:370 or 378 or 01:146:370.

01:146:471 Advanced Cell Biology Laboratory (3) Advanced laboratory methods in cell biology. Emphasis on light and electron microscopy, imaging, immunocytochemical techniques, tissue culture, and methods of identifying and separating macromolecules.� Prerequisites: 01:146:470 and permission of instructor.

01:146:472 Advanced Developmental Biology (3)

Molecular biology of early development, morphogenesis, organogenesis, tissue interactions, and genetic control of cellular differentiation.

Prerequisite: 01:146:270.

01:146:474 Immunology (3) Fundamental principles of immunology with emphasis on antibody�formation, immunoglobulin molecules and genes, hypersensitivity reactions, and the cellular basis for the immune response. Prerequisites: 01:119:101-102 and 01:447:380 or 384. Recommended: 01:447:390.

01:146:475 Laboratory in Immunology (1) Biochemical and molecular analysis of immune cell function. Application of immunological techniques to the examination of normal and diseased states.� Pre- or corequisite: 01:146:474.

01:146:478 Molecular Biology (3) Structure and function of macromolecules, recombinant DNA technology, and study of genes and their regulation at the molecular and cellular levels. Prerequisites: 01:160:307-308. For juniors and seniors only. Credit not given for both this course and 01:694:408 or 11:126:481.