16:663:501Medicinal Chemistry Research Techniques and Principles (3) For students preparing to do research in medicinal chemistry. Topics include information management, computer methods, basic laboratory techniques, bioassey techniques, metabolism, pro-drugs, and quantitative structure-activity relationships. Kimball, Rice, Weyand

16:663:502Principles of Drug Design (3) Principles of drug design. Topics include identifying new drug leads, drug absorption and distribution, pharmacomodulation, enzymes and receptors as targets, peptidomimetics, computer-aided drug design, and combinatorial chemistry. Hu, Kerrigan

16:663:504Strategies and Tactics in Synthetic Medicinal Chemistry (3) Strategies and tactics for the design of syntheses for organic pharmaceutical agents; strategies for the preparation of series of analogs for structure-activity investigations. Kimball, Rice. Prerequisite: 16:160:503.

16:663:505Drugs: Structure and Function (3) Survey of the major pharmaceutical agents in clinical use. Emphasis on the influence of chemical structure in the elicitation of pharmacological effects. LaVoie, Rice, Weyand. Prerequisites: 01:160:305,306 or equivalent.

16:720:507Advanced Pharmaceutics I (3) Application of physical-chemical principles to the study and evaluation of pharmaceutical systems: solubility phenomena, equilibria, complexation, phase transitions, and pharmaceutical stability, and the fundamentals of pharmacokinetics. Sinko. Prerequisites: Physical chemistry and associated math requirements.

16:720:509Advanced Pharmaceutics II (3) Kinetics aspects of the pharmaceutical sciences. Quantitative and mechanistic approaches to pharmacokinetics, dissolution rate, and chemical kinetics. Kong. Prerequisites: Ordinary differential equations (or equivalent) and pharmacokinetics.

16:720:510Advanced Pharmacokinetics (3) Kinetics of drug absorption, distribution, and elimination; clearance concepts; compartmental, noncompartmental, and physiological models. Sinko. Prerequisites: 01:160:327,328.

16:720:520Therapeutic Peptides and Delivery Systems (3) Study of biochemical, biopharmaceutical, and pharmacologic bases of peptide- and protein-based macromolecular drugs, and application of multidisciplinary approaches to their formulation, development, and systemic delivery. Knipp. Prerequisites: 01 or 11:115:301; 30:721: 301,302, 403,404, or permission of instructor.

16:720:522Controlled Drug Delivery Release (3) Multidisciplinary approaches to concepts, fundamentals, and biomedical assessments in the research and development of novel drug delivery systems. Cook. Prerequisites: 16:720:507, 515,516.

16:720:540Independent Research Proposal (3) Develop a written research proposal using the standard HHS/ NIH format as part of the Ph.D. degree requirements. Proposal is evaluated as to its originality, scientific merit, and quality. Enrollment limited to Ph.D. candidates with approval of their adviser.

16:720:601,602Seminar in Pharmaceutical Science (1,1) Presentation and discussion of recent developments in the pharmaceutical sciences.

16:720:607,608Special Topics (3,3) Selected topics in pharmaceutical science.

16:720:609Molecular and Functional Genomic Aspects of Membrane Transport (3) You

16:720:610,611Independent Study in Pharmaceutical Science (BA,BA) Independent library and/or laboratory research into special aspects of pharmaceutical science; arranged under the supervision of a specific faculty member. No more than 3 credits may be taken as part of a student`s program.

16:720:612,613Current Topics in Pharmaceutical Science (1,1) Seminar with lectures by scientists from the pharmaceutical industry on advanced topics within a particular area of pharmaceutical science, such as medicinal chemistry, pharmaceutical analysis, and pharmaceutics.

16:720:701,702Research in Pharmaceutical Science (BA,BA)

16:960:590Design of Experiments (3)