In addition to being an integral part of the university, the school is a vital part of the New Brunswick community. Designated as one of the state's most significant areas for education and health care, the city is home to Rutgers' largest regional campus (including its historic Old Queen's Campus) and to the Robert Wood Johnson Medical School of the University of Medicine and Dentistry of New Jersey, Saint Peter's University Hospital, and the Cancer Institute of New Jersey.

Its award-winning building, shared with Rutgers Mason Gross School of the Arts, is situated at Civic Square in New Brunswick, where it occupies an essential place in central New Jersey's educational and cultural hub. The locale includes a thriving cultural area--the State Theatre, George Street Playhouse, and Crossroads Theatre Company are steps away, and a wide variety of restaurants provide menus for every taste.

Civic Square is a five-minute walk to the city's train station, which has connections to Amtrak as well as local stops between New York City and Philadelphia on New Jersey Transit, both a 45-minute train ride away, while Washington, D.C., and Boston are accessible in just a few hours. The Bloustein School also is within minutes of three of the state's major highways.