16:718:565,566Advanced Problems in Pharmacology (BA,BA) Independent research with a faculty member on some aspect of a research problem. With minimum supervision, students are expected to analyze, interpret, and report the experimental data. Prerequisites: Permission of graduate director and instructor. |
16:718:574Neuropharmacology (2) Seminar presentations consider the mechanisms of synaptic transmission in the nervous system, role of voltage- and ligand-gated ion channels, and G-protein coupled receptors in information transmission. Material includes the regulation of the synthesis, storage, release, and destruction of neurotransmitters. Sonsalla. Prerequisite: Permission of instructor. |
16:718:578Drug Metabolism (2) Readings, seminars, and discussions emphasize selected papers from the primary literature pertaining to the metabolism of foreign chemicals. Critical discussions of publications that describe the properties and regulation of foreign compound-metabolizing enzymes in microorganisms, plants, insects, lower mammals, and humans. Consideration of the significance of these enzymes for the metabolism and action of foreign chemicals and endogenous substrates in intact cells and organisms. Conney, Kauffman. Prerequisite: Permission of instructor. |
16:718:581Hormones and Their Receptors (2) Modern theories of hormone action at the cellular and molecular levels. Familiarity with biochemistry, cell biology, and molecular biology is advisable. Chen, Fondell. Prerequisite: Permission of instructor. |
16:718:600Cancer Pharmacology (2) Mechanisms of actions of anti-tumor agents, design and discovery of anti-cancer drugs, and discovery of basic signaling mechanisms that constitute the targets of molecules used for cancer therapy. Novel strategies for cancer drug discovery. Jin, Liu. Prerequisite: Permission of instructor. |
16:718:601Genetics in Pharmacology (2) Genetic strategies in understanding drug mechanisms and in the search for new pharmaceutically active agents. Some familiarity with genetics advisable. Walworth. Prerequisite: Permission of instructor. |
16:718:602Seminar in Pharmacology (1) Faculty and student presentations. |
16:718:603Genomics in Cancer Therapeutics (3) The application of genomics for target discovery using DNA microarrays, target identification for cancer therapeutics based on abnormalities in the cancer cell versus the normal cell and non- invasive imaging of tumors. Gene therapy and differentiation therapy strategies for attacking the tumor cell based on knowledge gained from functional genomics of the tumor cell. Banerjee. Prerequisite: Permission of instructor. |
16:718:604Signal Transduction (2) Biology, pharmacology, and molecular biology of the cell cycle. Ryazanov. Prerequisite: Permission of instructor. |
16:718:605Drug-Target Interactions (2) Basic principles of the secondary and tertiary structures of nucleic acids used to explore aspects of nucleic acid biology such as protein-nucleic acid interactions, RNA-catalyzed reactions, and nucleic acid pharmacology. Gartenberg. Prerequisite: Permission of instructor. |
16:718:680Cellular and Molecular Pharmacology: Principles of Drug Action and Targeting (3) Molecular basis of pharmacologic selectivity, drug targets, adaptive responses to drugs, disposition of drugs, and genetic and molecular approaches to drug therapy. Pilch. Prerequisites: Permission of graduate director and instructor. |
16:718:701,702Research in Pharmacology (BA,BA) |
